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Neonatal alloimmune thrombocytopenia
Blood Reviews, 1989Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus. Bleeding may be severe; intracranial haemorrhage and permanent neurological damage are the most serious complications. Despite the severity of
P O, Skacel, M, Contreras
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Journal of Pediatric Hematology/Oncology, 2003
Alloimmunization against platelet antigens may take place during pregnancy and following transfusion or transplantation. The resulting antibodies bind to the target platelet antigens and may lead to a rapid sequestration of incompatible platelets.
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Alloimmunization against platelet antigens may take place during pregnancy and following transfusion or transplantation. The resulting antibodies bind to the target platelet antigens and may lead to a rapid sequestration of incompatible platelets.
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Neonatal Alloimmune Thrombocytopenia
Transfusion Medicine Reviews, 1994EONATAL alloimmune thrombocytopenia (NAIT) is a relatively rare disease, occurring in 1 in 3,000 to l in 5,000 births. 1.2 The platelet equivalent of hemolytic disease of the newbom, NAIT is the result of matemai alloimmunization against a platelet antigen present on fetal and pa ternal platelets but absent on matemai platelets.
M, Goldman +4 more
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Fetomaternal alloimmune thrombocytopenia
Transfusion and Apheresis Science, 2001Thrombocytopenia is the second commonest haematological abnormality in the neonatal period after anaemia due to iatrogenic blood letting. One to four percent of all newborn babies have a platelet count < 150 x 10(9)/l at birth and approximately 20-40% of neonates in intensive care units are affected by neonatal thrombocytopenia.
R, Ahya, M L, Turner, S J, Urbaniak
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Vox Sanguinis, 1993
The Winnipeg Rh Laboratory has reviewed its experiences with maternal CW alloimmunization. From September 24, 1956, to March 31, 1992, 12 women with significant CW alloimmunization underwent 18 pregnancies. In 3 (4 pregnancies) the antibody, despite its strength, was 'naturally occurring' (i.e. there was no known exposure to CW-positive red cells). The
J M, Bowman, J, Pollock
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The Winnipeg Rh Laboratory has reviewed its experiences with maternal CW alloimmunization. From September 24, 1956, to March 31, 1992, 12 women with significant CW alloimmunization underwent 18 pregnancies. In 3 (4 pregnancies) the antibody, despite its strength, was 'naturally occurring' (i.e. there was no known exposure to CW-positive red cells). The
J M, Bowman, J, Pollock
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Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2009
Alloimmunization is the formation of antibodies when there is an exposition of the individual to non-self antigens, as it occurs, for example, in the transfusion of incompatible blood and pregnancies, in whom the fetus express in its sanguineous cells antigens exclusively of paternal origin.
Eduardo, Baiochi +1 more
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Alloimmunization is the formation of antibodies when there is an exposition of the individual to non-self antigens, as it occurs, for example, in the transfusion of incompatible blood and pregnancies, in whom the fetus express in its sanguineous cells antigens exclusively of paternal origin.
Eduardo, Baiochi +1 more
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Neonatal Alloimmune Thrombocytopenia
Therapeutic Apheresis, 2002Abstract: Neonatal alloimmune thrombocytopenia (NAIT) can occur when a mother is immunized against fetal platelet antigens inherited from the father. Early diagnosis and appropriate platelet transfusion therapy are essential to prevent life‐threatening intracranial hemorrhage in the thrombocytopenic fetus or neonate.
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Neonatal alloimmune thrombocytopenia
Prenatal Diagnosis, 1995R, Warwick, P, Bennett
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