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HLA-Alloimmunization in Pregnancy
Fetal Diagnosis and Therapy, 1989The authors analyzed the correlations between the presence of anti-HLA antibodies and fetal neonatal problems. There are specific data in the literature on the protective effect of anti-HLA antibodies against abortion. Nevertheless our study shows a significant correlation between their presence and perinatal problems.
Giuseppe Noia+3 more
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The Impact of Sex on Alloimmunity
Trends in Immunology, 2018Transplantation outcomes are known to be affected by multiple factors, including donor and recipient sex. Aside from the physiological characteristics of male and female donor allografts, accumulating evidence suggests that additional features underlie sex-specific immune responses that affect graft survival.
Ashley Lau+2 more
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Fetomaternal alloimmune thrombocytopenia
Transfusion and Apheresis Science, 2001Thrombocytopenia is the second commonest haematological abnormality in the neonatal period after anaemia due to iatrogenic blood letting. One to four percent of all newborn babies have a platelet count < 150 x 10(9)/l at birth and approximately 20-40% of neonates in intensive care units are affected by neonatal thrombocytopenia.
R. Ahya+3 more
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Neonatal Alloimmune Thrombocytopenia
Transfusion Medicine Reviews, 1994EONATAL alloimmune thrombocytopenia (NAIT) is a relatively rare disease, occurring in 1 in 3,000 to l in 5,000 births. 1.2 The platelet equivalent of hemolytic disease of the newbom, NAIT is the result of matemai alloimmunization against a platelet antigen present on fetal and pa ternal platelets but absent on matemai platelets.
Mindy Goldman+4 more
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Transfusion, 2019
Alloantibodies recognizing human leukocyte antigens (HLA) can cause immune‐mediated refractoriness to platelet transfusion. An association between HLA alloimmunization and red blood cell (RBC) alloimmunization has been suggested but remains uncertain.
R. Belizaire+5 more
semanticscholar +1 more source
Alloantibodies recognizing human leukocyte antigens (HLA) can cause immune‐mediated refractoriness to platelet transfusion. An association between HLA alloimmunization and red blood cell (RBC) alloimmunization has been suggested but remains uncertain.
R. Belizaire+5 more
semanticscholar +1 more source
Foetal and neonatal alloimmune thrombocytopenia
Best Practice & Research Clinical Obstetrics & Gynaecology, 2019Foetal or neonatal thrombocytopenia results from alloimmunisation during pregnancy. Maternal alloantibodies can be formed following exposure to paternally derived human platelet antigens (HPAs) on foetal platelets, in case of incompatible HPA type. These alloantibodies are of the immunoglobulin G subclass and can therefore enter the foetal circulation ...
Winkelhorst, D., Oepkes, D.
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Leukodepletion and Alloimmunization
1995Platelet alloimmunization remains a dilemma in the management 1 of hematology patients since so little can be done to provide the necessary platelet transfusion support. A number of recent studies have provided information about the role of the passenger leukocytes that remain in blood products and how these initiate antibody development by ...
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Transfusion Clinique et Biologique, 2006
The RhD protein is expressed only on human red blood cells (RBC), and is one of the most immunogenic of the blood groups. It is of clinical importance since the alloantibody (anti-D) can hemolyse D positive RBC after blood transfusion, or cause hemolytic disease of the newborn.
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The RhD protein is expressed only on human red blood cells (RBC), and is one of the most immunogenic of the blood groups. It is of clinical importance since the alloantibody (anti-D) can hemolyse D positive RBC after blood transfusion, or cause hemolytic disease of the newborn.
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Alloimmunization in twin pregnancies
American Journal of Obstetrics and Gynecology, 1985Of 118 twins born of 59 alloimmunized mothers from 1944 to 1984, 65 were Rh-positive and six died. One twin in one of the 59 sets and four sets of twins referred from elsewhere underwent intrauterine fetal transfusion. The Manitoba twin and two pairs of the four referred sets survived. Fetal transfusions were begun at 22 2/7 and 24 1/7 weeks' gestation
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