Results 101 to 110 of about 1,245,772 (241)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Responses of Biomass and Allometric Growth Equations of Juvenile Mangrove Plants to Salinity, Flooding, and Aboveground Competition

Horticulturae
China has implemented large-scale mangrove restoration and afforestation initiatives in recent years. However, there has been a paucity of research on the growth of mangrove seedlings in a composite stress environment and the allometric growth equation ...
Kaijie Hu, Wei Wang, Wei Qian, Nong Sheng, Jiliang Cheng, Yanmei Xiong   +5 more
doaj   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Allometric Equation for Biomass Estimation of Cordia africana Lam. in Tumata Chirecha Agroforestry Gedeo Zone: Implication for Sustainable Management and Climatic Change Mitigation [PDF]

, 2016
Species specific allometric equation is important for accurate net aboveground biomass estimation and quantifying carbon stock in living tree biomass of terrestrial ecosystems. This study was undertaken to develop species-specific allometric equation non-
Mulat, Abiy
core   +1 more source

Development of allometric equation for biomass of rubber tree (hevea brasilliensis) saplings

, 2015
Carbon is sequestered by plant through photosynthesis and stored as biomass in different parts of the tree including stems, branches, leaves and roots. The objective of this study is to determine the biomass in five different growth stages of rubber tree
Azhanie Sardangi
core  

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Estimating crown biomass of three coniferous tree species using cross-sectional area at the base of live crown

Forest Systems
Aim of study: The error in estimating branch biomass, foliage biomass, and crown biomass (i.e. sum of branch and foliage biomass) based on the diameter at the live crown base was evaluated.
Satoshi Tatsuhara
doaj   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Allometric equations for estimating fresh biomass of five soil macroinvertebrate species from neotropical agroecosystems

, 2017
Accurate estimation of soil macroinvertebrate fresh biomass is crucial to link macroinvertebrate community to ecosystem functions, but remains a challenging task under field conditions.
Mathieu Coulis, Joly, François-Xavier, François-Xavier Joly, Coulis, Mathieu   +3 more
core   +1 more source