Results 111 to 120 of about 1,245,772 (241)

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Spatial variation in liana effects on host‐tree allometry and biomass in an intact tropical forest

Ecography, EarlyView.
Lianas are increasing in abundance across the tropics, yet local spatial variation in their effects on host‐tree allometry and biomass, and the drivers of this variation within forests, remain poorly understood. Using field inventory, drone photogrammetry, and terrestrial laser scanning (TLS) across a 50‐ha plot on Barro Colorado Island, Panama, we ...
Sruthi M. Krishna Moorthy, Félicien Meunier, Stefan A. Schnitzer, Kim Calders, David M. DeFilippis, Antonio Aguilar, Nancy Pausenberger, Marco D. Visser, Helene C. Muller‐Landau, Hans Verbeeck   +9 more
wiley   +1 more source

Simultaneous 3/4‐power scaling of leaf mass and 2/3‐power scaling of leaf area with stem mass in plants

Grassland Research, EarlyView.
Abstract Background Plant allometry theory developed in the last century focused on 2/3‐power scaling, determined by light interception considerations. More recently, 3/4‐power scaling based on the properties of vascular distribution networks has been proposed.
Cory Matthew, Hans Pretzsch, Rüdiger Grote   +2 more
wiley   +1 more source

Development of an allometric model to estimate above-ground biomass of forests using MLPNN algorithm, case study: Hyrcanian forests of Iran

Caspian Journal of Environmental Sciences, 2016
This research develops an allometric model for estimation of biomass based on the height and DBH of trees in the Hyrcanian forests of Iran. An accurate allometric model reduces the uncertainty of allometric equation in biomass estimation using radar ...
Sharifi, A., Amini, J., Pourshakouri, F.
doaj  

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain incompletely understood.
Cristiana Livramento Oliveira Pinto, Nicoly Caixêta Gonçalves, Paula Rafaela Queiroz da Silva, Ludmila Rodrigues Pontes, Juliana Reis Machado, Virmondes Rodrigues Jr., Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +7 more
wiley   +1 more source

Allometric Equation for Predicting the Aboveground Biomass of Timber Trees and Bamboos

, 2014
近年來自簽署京都議定書後，木本植物及森林對於CO2吸存的貢獻成為矚目的焦點，森林生物量的研究也再度引起重視。因為森林生物量為計算碳貯存量的基礎，生物量和碳貯存量二者間具有密切的相關性，碳貯存量可透過生物量之碳含量百分比(PCC)或碳濃度來計算碳貯存量，目前這類研究被廣泛地應用於森林碳貯存量的估算。生物量的推估對森林碳貯存量的估算而言是最重要的工作，目前多以建立胸高直徑（DBH）與個別林木生物量的關係式推導，並廣泛被應用在森林生物量的推估。過去多數生物量研究所建立的DBH與生物量相對關係式 ...
孫正華, Sun, Cheng-Hua
core  

Periodontitis and its association with left ventricular geometry and function: A cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background This study investigated the cross‐sectional association between periodontal status and left ventricular (LV) geometry and function, an early and prognostically relevant marker of cardiovascular disease. Methods Data were drawn from two population‐based cohorts in the Study of Health in Pomerania (SHIP): SHIP‐START‐2 (N = 2333) and ...
Maja Trost, Till Ittermann, Birte Holtfreter, Christiane Pink, Marcus Dörr, Henry Völzke, Matthias Nauck, Marcello Ricardo Paulista Markus, Thomas Kocher   +8 more
wiley   +1 more source

Overview of the re‐evaluation of trace elements as nutritional feed additives in the European Union: characterization, safety, and efficacy

Journal of the Science of Food and Agriculture, EarlyView.
Abstract The re‐evaluation of feed additives in the European Union was outlined in the Regulation (EC) No 1831/2003. The primary objectives were to ensure safety and verify efficacy, as well as to update authorizations and phase out unsafe additives or those in which the industry expressed no interest.
Gloria López‐Gálvez, Maria de Lourdes Bastos, Francesco Cubadda, Mikolaj A Gralak, Christer Hogstrand, Matteo L Innocenti, Joop de Knecht, Marta López‐Alonso, Alberto Mantovani, Alena Pechová, Fernando Ramos, Jürgen Gropp   +11 more
wiley   +1 more source