Results 131 to 140 of about 1,245,772 (241)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Phytotherapy Research, EarlyView.
Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie, Wumin Dai, Lu Sun, Wangang Gong, Tao Zhu, Yingli Zhang   +5 more
wiley   +1 more source

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

Phytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang, Jing Wang, Tianyi Wang, Qihao Fu, Jiawen Xu, Chaochen Li, Zheng Zhou, Chenxi Zhang, Guanhua Xu, Mingjie Xia, Zhiming Cui   +10 more
wiley   +1 more source

Allometric scaling for predicting human drug clearance

, 2005
Various modified methods have been proposed in response to criticisms regarding the practical applicability of allometric scaling, which is one of the most widely used approaches in predicting human drug clearance based on data from animal species.
Tang, Huadong
core   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Allometric equations for estimating tree volume and aboveground biomass of Acacia mangium Willd. on the Batéké Plateau, Republic of the Congo. [PDF]

PLoS One
Desarmes C, Loubota Panzou GJ, Hirsch F, Bertaux P, Bayol N.   +4 more
europepmc   +1 more source

Movement and Space Use Patterns of the Beale's Eyed Turtle (Sacalia bealei) Suggest Sensitivity to Environmental Changes and Poaching 比氏眼斑龟 (Sacalia bealei) 的活动与空间利用模式揭示其对环境变化及盗猎的敏感性

Wildlife Letters, EarlyView.
Using radiotelemetry, we found that the movement and home range of the endangered Sacalia bealei varied significantly across reproductive classes and seasons, with males exhibiting greater movement than females during wet and mating seasons. The species exhibits strong aquatic dependence, favoring deep pools interspaced among riffle‐pool sequences ...
Wing Sing Chan, Jonathan J. Fong, Timothy C. Bonebrake, Yik‐Hei Sung   +3 more
wiley   +1 more source

Altitudinal and slope gradients as key determinants of Robinia pseudoacacia growth. [PDF]

PLoS One
Shao Y, Hou L, Li Y, Zhang Z, Nie J, Xiao Y, Wang Z, Xin J, Wang N.   +8 more
europepmc   +1 more source

Diet, phenology and body size shape nutrient release by songbirds

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Animals can dramatically alter ecosystem structure and function through the cycling and transport of nutrients in their waste. While birds are particularly capable of influencing nutrient cycles due to their high mobility, abundance, metabolism and functional diversity,
Linsey Chen, Alexander S. Flecker, Ethan S. Duvall   +2 more
wiley   +1 more source