Results 141 to 150 of about 16,947 (261)

Human Pharmacokinetic Prediction of Antibody-Drug Conjugates Using Human FcRn Transgenic Mice. [PDF]

Clin Transl Sci
Nakagawa K, Haraya K.
europepmc   +1 more source

Home and away: allometry and climate drive morphology of European rabbits in their native and introduced range

Oikos, EarlyView.
Climatic conditions shape phenotypic evolution by driving adaptations that optimise organismal function. Invasive species provide valuable systems to study these processes, as they often encounter novel climatic conditions in their introduced ranges. The European rabbit Oryctolagus cuniculus, native to the Iberian Peninsula, has established populations
Rishab Pillai, Natasha Lee Hiotis, Christine Böhmer, Cécile Callou, Thomas J. Nelson, Irina Ruf, Thomas J. Sanger, Julia Schaar, Kévin Le Verger, Madeleine Geiger, Brian Kraatz, Emma Sherratt   +11 more
wiley   +1 more source

Improving carbon stock estimates in plantation forestry: Site-specific allometric equations for Gmelina arborea in Ghana's Kwahu Highlands. [PDF]

PLoS One
Asare BW, Ansong M, Boadu KB, Owusu P.
europepmc   +1 more source

The integrated reproductive response: the scope for seasonal phenotypic flexibility shapes reproductive outcomes across fish populations

Oikos, EarlyView.
Across north‐temperate environments, rapid environmental change has disrupted the seasonal life histories of resident organisms, decreasing the reliability of environmental cues. Flexible responses capable of buffering the effects of unpredictable environmental variation to defend performance and reproductive outcomes may thus be key to species‐ and ...
Timothy J. Fernandes, Sofia Pereira, Brian J. Shuter, Bailey C. McMeans   +3 more
wiley   +1 more source

An allometric large-scale analysis of the observed performance limits and sex differences in elite powerlifting. [PDF]

Front Physiol
Montenegro S, Wicker P, Donath L.
europepmc   +1 more source

Warming and predation drive rapid evolution of ecosystem functioning but not functional traits

Oikos, EarlyView.
Global environmental change can rapidly reshape phenotypic trait distributions through adaptive and neutral processes. Yet, disentangling their relative contributions remains a major challenge, particularly for traits underpinning ecosystem functioning.
Laure Olazcuaga, Emma Couranjou, Laura Fargeot, Allan Raffard, Romain Bertrand, Murielle Richard, Kéoni Saint‐Pé, Jérôme G. Prunier, Simon Blanchet   +8 more
wiley   +1 more source

Beyond Body Weight: A Comprehensive Review of Allometric Scaling in Drug Development for Human Dose Predictions. [PDF]

Pharmaceutics
Mallillin MC, Silva DA, Miller NA, Zhao S, Salami M, Löbenberg R, Davies NM.   +6 more
europepmc   +1 more source

Integrating vision, audition and olfaction traits: a roadmap for contrasting sensory ecologies of birds and rodents

Oikos, EarlyView.
Sensory ecology seeks to understand how organisms detect and use information from their environment, yet comparative analyses across multiple sensory modalities remain rare. Here, we present a roadmap for contrasting the sensory ecologies of birds and rodents using surrogate morphological and acoustic traits associated with vision, audition, and ...
Raphaël Proulx, Josyane Brouillard, Laurie Provençal, Frédérick Girard, Jessica Bertolacci, Youri Simard   +5 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling to predict human pharmacokinetics of a novel mithramycin analog for Ewing sarcoma. [PDF]

Cancer Chemother Pharmacol
Niloy KK, Horn J, Bhuiyan NH, Bhosale SS, Shaaban KA, Prisinzano TE, Thorson JS, Rohr J, Leggas M.   +8 more
europepmc   +1 more source

Informing the potential of mature temperate forests as natural climate solutions: Changed fine root biomass and morphology under elevated CO2

PLANTS, PEOPLE, PLANET, EarlyView.
The land carbon sink absorbs approximately 25% of anthropogenic CO2 emissions, with forests accounting for most. Managing forests as Natural Climate Solutions is therefore a societal imperative, requiring models of where and how long carbon resides within these ecosystems. We investigated the effects of elevated CO2 on fine roots, the primary source of
Grace Handy, Angeliki Kourmouli, Marie Arnaud, Carolina Mayoral, Richard J. Norby, Michaela K. Reay, Sami Ullah, Iain P. Hartley, R. Liz Hamilton, Robert Grzesik, Andy R. Smith, Elena Vanguelova, A. Rob MacKenzie, Adriane Esquivel‐Muelbert   +13 more
wiley   +1 more source