Results 171 to 180 of about 151,004 (296)

Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure. [PDF]

J Chem Theory Comput
Xie S, Yildiz CB, Ruggerone P, Zuo K, Zimmer-Bensch G, Carloni P.   +5 more
europepmc   +1 more source

Integrating NMR and contact-response analysis reveals the allosteric network driving domain closure in Enzyme I. [PDF]

Proc Natl Acad Sci U S A
Singh A, Burns D, Sedinkin SL, Das S, Potoyan DA, Venditti V.   +5 more
europepmc   +1 more source

Synthesis of novel allosteric modulators of the G-protein coupled receptor CB1

, 2015
CB1 allosteric modulators provide new opportunities to specifically regulate biological responses mediated by CB1 receptor. This approach is an attempt to infer information about the mode of binding interactions and signaling efficacy produced by ...
Samala, Sushma
core  

Decoding the allosteric grammar of protein kinases: A dual-stream framework integrating protein language models and energy landscape frustration analysis. [PDF]

Protein Sci
Gatlin W, Ludwick M, Turano L, Foley B, Riedlová K, Škrhák V, Novotný M, Hoksza D, Verkhivker GM.   +8 more
europepmc   +1 more source

Mapping of dynamic allostery within p38 alpha kinase via network analyses and NMR spectroscopy. [PDF]

Nat Commun
Roy Acharyya S, Weisner J, Bernardi RC, Linser R.   +3 more
europepmc   +1 more source

Explainable AI reveals the allosteric blind spot in protein-ligand binding predictions. [PDF]

Cell Rep Phys Sci
Parikh V, Foley B, Gatlin W, Ludwick M, Turano L, Verkhivker GM.   +5 more
europepmc   +1 more source

Assessing clinical relevance of off-target effects observed at suprapharmacological concentrations of SGLT2 inhibitors. [PDF]

J Clin Invest
Taylor SI.
europepmc   +1 more source

Towards better outcomes for epidermal growth factor receptor L858R+ lung cancer patients: mutant-selective allosteric inhibitors and the potential for double-drugging. [PDF]

Philos Trans R Soc Lond B Biol Sci
Eck MJ, Scott DA.
europepmc   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source