Fc-Binding Cyclopeptide Induces Allostery from Fc to Fab: Revealed Through in Silico Structural Analysis to Anti-Phenobarbital Antibody [PDF]
FoodsAllostery is a fundamental biological phenomenon that occurs when a molecule binds to a protein’s allosteric site, triggering conformational changes that regulate the protein’s activity.
Tao Zhou +6 more
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Structurally distributed surface sites tune allosteric regulation
eLife, 2021 Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed?
James W McCormick +4 more
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Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles
Biomolecules, 2022 Allostery—regulation at distant sites is a key concept in biology. The proteasome exhibits multiple forms of allosteric regulation. This regulatory communication can span a distance exceeding 100 Ångstroms and can modulate interactions between the two ...
Philip Coffino, Yifan Cheng
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Allostery: An Overview of Its History, Concepts, Methods, and Applications. [PDF]
PLoS Computational Biology, 2016 The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961 ...
Jin Liu, Ruth Nussinov
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Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations. [PDF]
PLoS Computational Biology, 2016 Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein.
Samuel Hertig +2 more
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Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery. [PDF]
PLoS Computational Biology, 2016 Intra-protein information is transmitted over distances via allosteric processes. This ubiquitous protein process allows for protein function changes due to ligand binding events.
Robert Kalescky +3 more
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Nature Communications, 2023 Biological regulation ubiquitously depends on protein allostery, but the regulatory mechanisms are incompletely understood, especially in proteins that undergo ligand-induced allostery with few structural changes. Here we used hydrogen-deuterium exchange
Anum Glasgow +5 more
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Allosteric crosstalk in modular proteins: Function fine-tuning and drug design
Computational and Structural Biotechnology Journal, 2023 Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells.
Suman Abhishek +4 more
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Allostery through DNA drives phenotype switching
Nature Communications, 2021 Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long ...
Gabriel Rosenblum +5 more
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Role of water-bridged interactions in metal ion coupled protein allostery.
PLoS Computational Biology, 2022 Allosteric communication between distant parts of proteins controls many cellular functions, in which metal ions are widely utilized as effectors to trigger the allosteric cascade.
Xingyue Guan +4 more
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