Results 1 to 10 of about 10,740 (213)

Allostery Frustrates the Experimentalist [PDF]

Journal of Molecular Biology, 2023
Proteins interact with other proteins, with nucleic acids, lipids, carbohydrates and various small molecules in the living cell. These interactions have been quantified and structurally characterized in numerous studies such that we today have a comprehensive picture of protein structure and function.
Stefano Gianni, Per Jemth
exaly   +5 more sources

Protein Allostery at Atomic Resolution

Angewandte Chemie - International Edition, 2020
Confined by the Boltzmann distribution of the energies of states, motion is inherent to biomolecules. For a detailed understanding of a protein’s function, not only the 3D structure but also the description of its dynamics is thus required.
Dean Strotz, Julien Orts, Harindranath Kadavath   +2 more
exaly   +2 more sources

The ensemble nature of allostery [PDF]

Nature, 2014
Allostery is the process by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to another, often distal, functional site, allowing for regulation of activity. Recent experimental observations demonstrating that allostery can be facilitated by dynamic and intrinsically disordered proteins have resulted in a new ...
Hesam N Motlagh, James O Wrabl, Vincent J Hilser   +2 more
exaly   +3 more sources

Allostery and cooperativity revisited [PDF]

Protein Science, 2008
Abstract Although phenomenlogical models that account for cooperativity in allosteric systems date back to the early and mid‐60's (e.g., the KNF and MWC models), there is resurgent interest in the topic due to the recent experimental and computational studies that attempted to reveal, at an atomistic level, how allostery actually ...
Qiang Cui
exaly   +3 more sources

Machine learning and protein allostery

Trends in Biochemical Sciences, 2023
Siân Xiao, Gennady M Verkhivker, Peng Tao   +2 more
exaly  

Renaissance of Allostery to Disrupt Protein Kinase Interactions

Trends in Biochemical Sciences, 2020
Alejandro E Leroux, Ricardo M Biondi
exaly  

Harnessing Allostery: A Novel Approach to Drug Discovery

Medicinal Research Reviews, 2014
Shaoyong Lu, Shuai Li
exaly  

Allostery in Its Many Disguises: From Theory to Applications

Structure, 2019
Emanuele Paci, Nikolay V Dokholyan, Igor N Berezovsky   +2 more
exaly  

Is allostery an intrinsic property of all dynamic proteins?

Proteins: Structure, Function and Bioinformatics, 2004
K Gunasekaran, Buyong Ma, Ruth Nussinov   +2 more
exaly  

NMR insights into protein allostery

Archives of Biochemistry and Biophysics, 2012
Gregory Manley, J Patrick Loria
exaly