Results 41 to 50 of about 18,856 (214)

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

mAbs, 2023
Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in ...
Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman   +5 more
doaj   +1 more source

Architecture and Co-Evolution of Allosteric Materials

, 2016
We introduce a numerical scheme to evolve functional materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures and the correlations among them can be computed.
Brito, Carolina, Ravasio, Riccardo, Wyart, Matthieu, Yan, Le   +3 more
core   +1 more source

Allostery

Quarterly Reviews of Biophysics
Abstract Allostery describes the ability of biological macromolecules to transmit signals spatially through the molecule from an allosteric site – a site that is distinct from orthosteric binding sites of primary, endogenous ligands – to the functional or active site.
Mateu Montserrat-Canals, Gabriele Cordara, Ute Krengel   +2 more
openaire   +2 more sources

A Time-Dependent Quantum Approach to Allostery and a Comparison With Light-Harvesting in Photosynthetic Phenomenon

Frontiers in Molecular Biosciences, 2020
The allosteric effect is one of the most important processes in regulating the function of proteins, and the elucidation of this phenomenon plays a significant role in understanding emergent behaviors in biological regulation.
Giovanni Villani
doaj   +1 more source

Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes [PDF]

, 2016
Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known.
Echave, Julián, Jack, Benjamin R., Meyer, Austin G., Wilke, Claus O.   +3 more
core   +4 more sources

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

eLife, 2017
Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery.
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser   +9 more
doaj   +1 more source

Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase

Nature Communications, 2023
Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery.
Federica Maschietto, Uriel N. Morzan, Florentina Tofoleanu, Aria Gheeraert, Apala Chaudhuri, Gregory W. Kyro, Peter Nekrasov, Bernard Brooks, J. Patrick Loria, Ivan Rivalta, Victor S. Batista   +10 more
doaj   +1 more source

Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

iScience, 2021
Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer ...
Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M. Thayer, David L. Beveridge, Shalender Bhasin   +10 more
doaj   +1 more source

Evolution of sparsity and modularity in a model of protein allostery

, 2014
The sequence of a protein is not only constrained by its physical and biochemical properties under current selection, but also by features of its past evolutionary history.
Hemery, Mathieu, Rivoire, Olivier
core   +3 more sources

Probing Allostery Through DNA [PDF]

Science, 2013
Allostery Across DNA Proteins, such as transcription factors and RNA polymerase, bind close to each other on DNA and their function is coordinated. Kim et al. (p.
Kim, Sangjin, Broströmer, Erik, Jin, Jianshi, Chong, Shasha, Ge, Hao, Wang, Siyuan, Gu, Chan, Yang, Lijiang, Gao, Yi Qin, Su, Xiao-dong, Sun, Yujie, Xie, Xiaoliang, Xing, Dong   +12 more
openaire   +3 more sources