Results 51 to 60 of about 11,653 (194)
Allostery and Kinetic Proofreading [PDF]
The Journal of Physical Chemistry B, 2019 Kinetic proofreading is an error correction mechanism present in the processes of the central dogma and beyond, and typically requires the free energy of nucleotide hydrolysis for its operation. Though the molecular players of many biological proofreading schemes are known, our understanding of how energy consumption is managed to promote fidelity ...
Vahe Galstyan, Rob Phillips
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eLife, 2017 Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery.
Jing Li +9 more
doaj +1 more source
Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase
Nature Communications, 2023 Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery.
Federica Maschietto +10 more
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Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle
Frontiers in Molecular Biosciences, 2023 Biliverdin Reductase B (BLVRB) is an NADPH-dependent reductase that catalyzes the reduction of multiple substrates and is therefore considered a critical cellular redox regulator.
Eunjeong Lee +6 more
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Chemistry & Biology, 2004 Engineered RNAs have demonstrated remarkable properties of molecular recognition and allosteric function. Liu and colleagues now report the isolation and in vivo function of a ligand-dependent RNA-based transcription factor that opens wide the door for allosterically controllable aptamers.
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Dynamic Allostery: Evolution’s Double-Edged Sword in Protein Function and Disease [PDF]
Journal of Molecular BiologyBanu Özkan +2 more
exaly +2 more sources
Cell Reports, 2021 Summary: The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S
Sophie M.-C. Gobeil +11 more
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When Biology Meets Medicine: A Perspective on Foundation Models
Advanced Intelligent Discovery, EarlyView.Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu +3 more
wiley +1 more source
Disorder driven allosteric control of protein activity
Current Research in Structural Biology, 2020 Studies of protein allostery increasingly reveal an involvement of the back and forth order-disorder transitions in this mechanism of protein activity regulation.
Wei-Ven Tee +2 more
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Molecular Glue Degraders in Early Development for Cancer Therapy
Medicinal Research Reviews, EarlyView.ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir +4 more
wiley +1 more source