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A unified view of "how allostery works".
PLoS Computational Biology, 2014 The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second,
Chung-Jung Tsai, Ruth Nussinov
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Probing Allostery Through DNA [PDF]
Science, 2013 Allostery Across DNA Proteins, such as transcription factors and RNA polymerase, bind close to each other on DNA and their function is coordinated. Kim et al. (p.
Kim, Sangjin +12 more
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Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play [PDF]
Journal of Molecular Biology, 2008 Allostery is essential for controlled catalysis, signal transmission, receptor trafficking, turning genes on and off, and apoptosis. It governs the organism's response to environmental and metabolic cues, dictating transient partner interactions in the cellular network.
Tsai, Chung-Jung +2 more
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Biology DirectIt was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept of allosteric control was conceived and ...
Maurizio Brunori
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Structurally distributed surface sites tune allosteric regulation
eLife, 2021 Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed?
James W McCormick +4 more
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Biophysical Journal, 2016 G-protein-coupled receptors (GPCRs) constitute a large group of integral membrane proteins that transduce extracellular signals from a wide range of agonists into targeted intracellular responses. Although the responses can vary depending on the category of G-proteins activated by a particular receptor, responses were also found to be triggered by ...
Stuart J, Edelstein +1 more
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Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery. [PDF]
PLoS Computational Biology, 2016 Intra-protein information is transmitted over distances via allosteric processes. This ubiquitous protein process allows for protein function changes due to ligand binding events.
Robert Kalescky +3 more
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Nature Communications, 2023 Biological regulation ubiquitously depends on protein allostery, but the regulatory mechanisms are incompletely understood, especially in proteins that undergo ligand-induced allostery with few structural changes. Here we used hydrogen-deuterium exchange
Anum Glasgow +5 more
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Allosteric crosstalk in modular proteins: Function fine-tuning and drug design
Computational and Structural Biotechnology Journal, 2023 Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells.
Suman Abhishek +4 more
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Role of water-bridged interactions in metal ion coupled protein allostery.
PLoS Computational Biology, 2022 Allosteric communication between distant parts of proteins controls many cellular functions, in which metal ions are widely utilized as effectors to trigger the allosteric cascade.
Xingyue Guan +4 more
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