Results 21 to 30 of about 18,856 (214)
Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states.
PLoS Computational Biology, 2022 The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of ...
Amanda L Peiffer +4 more
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Mapping allosteric communications within individual proteins
Nature Communications, 2020 The computational prediction of protein allostery can guide experimental studies of protein function and cellular activity. Here, the authors develop a network-based method to detect allosteric coupling within proteins solely based on their structures ...
Jian Wang +5 more
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Frontiers in Pharmacology, 2021 Translocator protein 18 kDa (TSPO) is an evolutionarily conserved 5-transmembrane domain protein, and has been considered as an important therapeutic target for the treatment of pain.
Bojun Xiong +13 more
doaj +1 more source
Coarse-grained model of entropic allostery [PDF]
, 2004 Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via
A. Cooper +13 more
core +3 more sources
Allostery vs. “allokairy” [PDF]
Proceedings of the National Academy of Sciences, 2015 A hallmark feature of biological systems is that they are tightly regulated. Whether it is turning genes on and off, controlling cell division, or tuning the activity of enzymes, nature has evolved an intricate array of regulatory measures to ensure that systems can optimally respond to the myriad of environmental queues that determine everything from ...
Vincent J, Hilser +2 more
openaire +2 more sources
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]
, 2019 PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan +11 more
core +3 more sources
Entropy, 2015 In performing their biological functions, molecular machines must process and transmit information with high fidelity. Information transmission requires dynamic coupling between the conformations of discrete structural components within the protein ...
Michael V. LeVine, Harel Weinstein
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Known allosteric proteins have central roles in genetic disease.
PLoS Computational Biology, 2022 Allostery is a form of protein regulation, where ligands that bind sites located apart from the active site can modify the activity of the protein. The molecular mechanisms of allostery have been extensively studied, because allosteric sites are less ...
György Abrusán +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Koumine is an alkaloid that displays notable activity against inflammatory and neuropathic pain, but its therapeutic target and molecular mechanism still need further study.
Bojun Xiong +15 more
doaj +1 more source
Possible mechanism and clinical potentials of allostery
Clinical and Translational Medicine, 2014 Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic.
Peixin Huang, Elena López Villar
doaj +1 more source