Results 11 to 20 of about 18,856 (214)
Combinatorial Control through Allostery [PDF]
The Journal of Physical Chemistry B, 2018 Many instances of cellular signaling and transcriptional regulation involve switch-like molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical ...
Einav, Tal +3 more
core +10 more sources
Biology DirectIt was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept of allosteric control was conceived and ...
Maurizio Brunori
doaj +3 more sources
Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition. [PDF]
BioessaysAlong with peptides, MHC polymorphisms allosterically tune peptide energy landscapes, altering conformational dynamics and T cell receptor recognition. This dynamic allostery mechanism explains how subtle polymorphic differences drive differential immune specificity across individuals and populations.
Eldaly B, Baker BM.
europepmc +2 more sources
Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α. [PDF]
Angew Chem Int Ed EnglUsed in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Medina Gómez S +4 more
europepmc +2 more sources
Biophysical Journal, 2016 G-protein-coupled receptors (GPCRs) constitute a large group of integral membrane proteins that transduce extracellular signals from a wide range of agonists into targeted intracellular responses. Although the responses can vary depending on the category of G-proteins activated by a particular receptor, responses were also found to be triggered by ...
Stuart J, Edelstein +1 more
openaire +2 more sources
Trends in Genetics, 2014 Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers.
Raman, Srivatsan +4 more
openaire +3 more sources
Allostery in membrane proteins [PDF]
Current Opinion in Structural Biology, 2020 Membrane proteins are an integral part of signal transduction. To signal, membrane proteins must interact with a variety of lipid species, effectors, and other proteins in the biological membrane leading to an immense number of possible interactions. Despite this inherent complexity, accurate control of signaling must take place.
Cournia, Zoe, Chatzigoulas, Alexios
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Allostery Frustrates the Experimentalist
Journal of Molecular Biology, 2023 Proteins interact with other proteins, with nucleic acids, lipids, carbohydrates and various small molecules in the living cell. These interactions have been quantified and structurally characterized in numerous studies such that we today have a comprehensive picture of protein structure and function.
Gianni, Stefano, Jemth, Per
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Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites.
Choi, Sun, Hyeon, Changbong, Lee, Yoonji
core +7 more sources
The genotype‐phenotype landscape of an allosteric protein
Molecular Systems Biology, 2021 Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Yet a quantitative understanding of allosteric genotype‐phenotype relationships remains elusive.
Drew S Tack +8 more
doaj +1 more source