Results 11 to 20 of about 10,740 (213)
Allostery: An Overview of Its History, Concepts, Methods, and Applications. [PDF]
PLoS Computational Biology, 2016 The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961 ...
Jin Liu, Ruth Nussinov
doaj +3 more sources
Trends in Genetics, 2014 Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers.
Raman, Srivatsan +4 more
openaire +5 more sources
Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles [PDF]
Biomolecules, 2022 Allostery—regulation at distant sites is a key concept in biology. The proteasome exhibits multiple forms of allosteric regulation. This regulatory communication can span a distance exceeding 100 Ångstroms and can modulate interactions between the two ...
Philip Coffino, Yifan Cheng
doaj +2 more sources
Allostery in membrane proteins [PDF]
Current Opinion in Structural Biology, 2020 Membrane proteins are an integral part of signal transduction. To signal, membrane proteins must interact with a variety of lipid species, effectors, and other proteins in the biological membrane leading to an immense number of possible interactions. Despite this inherent complexity, accurate control of signaling must take place.
Zoe Cournia, Alexios Chatzigoulas
openaire +4 more sources
Journal of Molecular Biology, 2013 A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman.
Crick, F.H.C., Wyman, Jeffries
openaire +3 more sources
Fc-Binding Cyclopeptide Induces Allostery from Fc to Fab: Revealed Through in Silico Structural Analysis to Anti-Phenobarbital Antibody [PDF]
FoodsAllostery is a fundamental biological phenomenon that occurs when a molecule binds to a protein’s allosteric site, triggering conformational changes that regulate the protein’s activity.
Tao Zhou +6 more
doaj +2 more sources
Possible mechanism and clinical potentials of allostery
Clinical and Translational Medicine, 2014 Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic.
Peixin Huang
exaly +2 more sources
On the relationship between efficiency and cooperativity in multi-subunit molecular machines. [PDF]
Protein SciAbstract Two key properties of machines are the extent of coordination between their moving parts and their efficiencies. Here, we analyze how the extent of coordination, as reflected in cooperativity between subunits in an oligomeric molecular machine, affects its efficiency.
Ben-Maimon M, Horovitz A.
europepmc +2 more sources
Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations. [PDF]
PLoS Computational Biology, 2016 Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein.
Samuel Hertig +2 more
doaj +2 more sources
Allostery through DNA drives phenotype switching
Nature Communications, 2021 Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long ...
Gabriel Rosenblum +5 more
doaj +2 more sources