Results 41 to 50 of about 151,004 (296)
Multiple Routes to Oestrogen Antagonism
Pharmaceuticals, 2010 Several lines of evidence attest to the existence of alternative ligand binding sites on the oestrogen receptor (ER), including non-competitive inhibition by trilostane or tamoxifen.
Hilary R. Glover +4 more
doaj +1 more source
Exploration of Immunology, 2021 Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj +1 more source
Co-transcriptional allosteric regulation of synthetic nucleic acid receptors [PDF]
, 2023 We present a strategy to control allosterically the loading and release of molecular ligands from synthetic nucleic acid receptors using in vitro transcription.
Eiji, Nakamura +4 more
core +2 more sources
, 2023 This is the initial release to archive original code used for the RNA-Seq analysis performed in the manuscript "Allosteric-regulation-of-switch-II-controls-K-Ras-oncogenicity"
Bing Shui
core +1 more source
Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines [PDF]
Journal of the Serbian Chemical Society, 2016 A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine.
Penjišević Jelena Z. +6 more
doaj +1 more source
Biomolecules, 2022 Phospholipase D reacts with alcohols or water, transphosphatidylating or hydrolysing lipids such as phosphatidylcholine, generating phosphatidylalcohols or phosphatidic acid, respectively.
Hengzhang Yang, Rüdiger Woscholski
doaj +1 more source
FASTDock: A Pipeline for Allosteric Drug Discovery [PDF]
, 2023 Allostery is involved in innumerable biological processes and plays a fundamental role in human disease. Thus, exploration of allosteric modulation is crucial for research on biological mechanisms and in the development of novel therapeutics. Development
Charles, Brooks, Furyal, Ahmed
core +2 more sources
Allostery: allosteric networks and allosteric signaling bias
Quarterly Reviews of BiophysicsAbstract Allosteric communication is established by networks through which strain energy generated at the allosteric site by an allosteric event, such as ligand binding, can propagate to the functional site. Exerted on multiple molecules in the cell, it can wield a biased function. Here, we discuss
Ruth Nussinov +2 more
openaire +2 more sources
Multitargeting nature of muscarinic orthosteric agonists and antagonists
Frontiers in Physiology, 2022 Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
doaj +1 more source
Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair [PDF]
, 2012 The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
Susan McIntyre +13 more
core +1 more source