Results 171 to 180 of about 139,314 (301)

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source

<i>De Novo</i> Design in an M₁ Positive Allosteric Modulator Backup Program: The Discovery of VU6069863. [PDF]

ACS Med Chem Lett
Han C, Rathnayake U, Gregro AR, Engers JL, Presley CC, Schley ND, Thompson Gray AD, Bubser M, Cho HP, Rodriguez AL, Kramlinger VM, Boutaud O, Niswender CM, Jones CK, Engers DW, Lindsley CW.   +15 more
europepmc   +1 more source

Operationan Analysis of PLS 2.5 GeV Electron Linac Klystron-Modulator System

, 2004
1
남상훈, Y. J. Han, S. S. Park, S. H. Kim   +3 more
core  

Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions. [PDF]

Neuropsychopharmacology
Lauer J, Poppke J, Nickl-Jockschat T, Dieterich DC, Fendt M, Afzal S.   +5 more
europepmc   +1 more source

Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley   +1 more source

Discovery of VU6052959/BI'7927: A Selective mGlu₃ Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype. [PDF]

ACS Med Chem Lett
Jones CA, Duncan RA, Gilliland KM, Haymer DH, Spearing PK, Capstick RA, Roland BP, Vinson P, Quitalig M, Baggeroer C, Billard NB, Dickerson JW, Watson KJ, Kramlinger VM, Boutaud O, Ursu D, Wotjak CT, Priepke H, Garneau M, Trenz K, Niswender CM, Cho HP, Rook JM, Freiwald M, Giovannini R, Sommer H, Hobson S, Conn PJ, Melancon BJ, Lindsley CW, Reed CW.   +30 more
europepmc   +1 more source

Allosteric Modulators of Drug Targets [PDF]

Journal of Medicinal Chemistry, 2018
openaire   +2 more sources

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Radiosynthesis and preclinical evaluation of [¹¹C]Methyl-V-0219, a small molecule glucagon-like peptide-1 allosteric modulator for PET brain imaging. [PDF]

EJNMMI Radiopharm Chem
Lechi F, Khalil A, Bautista PN, Öberg J, Balestri LJI, Eriksson O, Eriksson J, Odell LR.   +7 more
europepmc   +1 more source

Cenobamate use in super‐refractory status epilepticus: A report of three cases

Epileptic Disorders, EarlyView.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +1 more source