Results 201 to 210 of about 19,325 (262)

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck. [PDF]

J Biol Chem
Selzer AM, Gerlach G, Gonzalez-Areizaga G, Wales TE, Cui SY, Iyer P, Engen JR, Camacho C, Ishima R, Smithgall TE.   +9 more
europepmc   +1 more source

Discovery of VU6007496: Challenges in the Development of an M₁ Positive Allosteric Modulator Backup Candidate. [PDF]

ACS Chem Neurosci
Engers JL, Bollinger KA, Capstick RA, Long MF, Bender AM, Dickerson JW, Peng W, Presley CC, Cho HP, Rodriguez AL, Niswender CM, Moran SP, Xiang Z, Blobaum AL, Boutaud O, Rook JM, Engers DW, Conn PJ, Lindsley CW.   +18 more
europepmc   +1 more source

Correction to: Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice. [PDF]

Psychopharmacology (Berl)
Scicluna RL, Everett NA, Badolato CJ, Wilson BB, Bowen MT.   +4 more
europepmc   +1 more source

Discovery of VU6024578/BI02982816: An mGlu₁ Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models. [PDF]

J Med Chem
Reed CW, Kalbfleisch JF, Turkett JA, Trombley TA, Nastase AF, Spearing PK, Haymer DH, Sarwar MM, Quitalig M, Dickerson JW, Blobaum AL, Boutaud O, Voehringer P, Schuelert N, Cho HP, Niswender CM, Rook JM, Priepke H, Ursu D, Conn PJ, Melancon BJ, Lindsley CW.   +21 more
europepmc   +1 more source

Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation. [PDF]

Front Pharmacol
Park SH, Heo Y, Kwon I, Jo S, Jeon H, Lee Y, Kim J, Heo JH, Namkung W.   +8 more
europepmc   +1 more source

An Acetylcholine M1 Receptor-Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment: A Phase 2 Randomized Clinical Trial.

JAMA Neurol
Shanbhag NM, Padmanabhan JL, Zhang Z, Harel BT, Jia H, Kangarloo T, Yin W, Dowling AV, Laurenza A, Khudyakov P, Galinsky K, Latzman RD, Simuni T, Weintraub D, Horak FB, Lustig C, Maruff P, Simen AA.   +17 more
europepmc   +1 more source