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Allosteric Modulation of G Protein-Coupled Receptors
Current Pharmaceutical Design, 2004The past decade has witnessed a significant growth in the identification of allosteric modulators of G protein–coupled receptors (GPCRs), i.e., ligands that interact with binding sites that are topographically distinct from the orthosteric site recognized by the receptor's endogenous agonist.
L T, May +3 more
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Allosteric Modulation of G-Protein–Coupled Receptors
Expert Opinion on Therapeutic Patents, 2001Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach for selectivity in drug action. Allosteric modulators that enhance or diminish the effects of (endogenous) agonists or antagonists on a variety of G protein-coupled receptors are described in this review, with emphasis on the latest developments
Willem, Soudijn +2 more
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The gut microbiome as a modulator of healthy ageing
Nature Reviews Gastroenterology and Hepatology, 2022Tarini S Ghosh +2 more
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Nonsense-mediated RNA decay: an emerging modulator of malignancy
Nature Reviews Cancer, 2022Kun Tan, Miles F Wilkinson
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An integrated magneto-optic modulator for cryogenic applications
Nature Electronics, 2022Paolo Pintus +2 more
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