Results 71 to 80 of about 139,314 (301)
Silicon electro-optic modulator [PDF]
, 2012 Electronic redacted version excludes material for which permission has not been granted by the rights holderIn recent years, as on-chip data transmission has increased dramatically, much time and effort has been devoted to the development of compact ...
Dong, Fengqiao
core +2 more sources
Potential allosteric modulators of the proteasome activity [PDF]
Biopolymers, 2010 AbstractProteasome, consisting of a tube‐shaped proteolytic core particle and attached to it regulatory modules, is a multifunctional enzymatic complex essential for the ubiquitin‐proteasome metabolic pathway. Due to its immense involvement in regulation of cellular physiology, the proteasome is an acknowledged anticancer drug target and potential ...
Elżbieta Jankowska +7 more
openaire +3 more sources
An Optical Modulator in Unmodified, Commercially-Available CMOS Technology [PDF]
, 2011 11/04/13 Meb. Accepted version, OK to pub.Here we present a method and structures for mid-infrared, free-space optical communication using unmodified, commercially available complementary metal-oxide semiconductor integrated circuits.
Nikolic, K +5 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Mechanism of Allosteric Modulation of the Cys-loop Receptors
Pharmaceuticals, 2010 The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker +2 more
doaj +1 more source
Allosteric modulators of metabotropic glutamate receptors: from virtual screening to experimental validation [PDF]
, 2007 The goal of this thesis was to gain further insight into the binding behavior of ligands in the heptahelical domain (HD) of group I metabotropic glutamate receptors (mGluRs).
Noeske, Tobias
core
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Allosteric modulation of DNA by small molecules [PDF]
Proceedings of the National Academy of Sciences, 2009 Many human diseases are caused by dysregulated gene expression. The oversupply of transcription factors may be required for the growth and metastatic behavior of human cancers. Cell permeable small molecules that can be programmed to disrupt transcription factor-DNA interfaces could silence aberrant gene expression pathways ...
Chenoweth, David M., Dervan, Peter B.
openaire +4 more sources
, 2023 Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator ...
Y Du (6951416) +10 more
core
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source