Results 121 to 130 of about 68,671 (251)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Allosteric regulation of enzymatic catalysis by molecular crowding. [PDF]

Commun Chem
Ren W, Lu J, Huang H, Zhang J, Chen Y, Yan Z, Li W, Wang W.   +7 more
europepmc   +1 more source

Protein‐Based High‐Performance Liquid Chromatography and Cyclodextrin‐Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles

ELECTROPHORESIS, EarlyView.
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Sarah Moreau, Amy Dillon, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP. [PDF]

Nat Commun
Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I.   +7 more
europepmc   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control. [PDF]

Protein Sci
Kim H, Feng S, Bohutskyi P, Li X, Mejia-Rodriguez D, Zhang T, Qian WJ, Cheung MS.   +7 more
europepmc   +1 more source

Allosteric regulation of kinase activity in living cells. [PDF]

Elife, 2023
Godbole SS, Dokholyan NV.
europepmc   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Human Transglutaminases: Updated Insights into Activation Mechanisms, Allosteric Regulation and Disease. [PDF]

Int J Mol Sci
Moya-Garrido P, Cano-Gómez LP, Ibarra-Molero B, Godoy-Ruiz R, Medina-Carmona E.   +4 more
europepmc   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source