Results 171 to 180 of about 2,237,466 (287)

Structural basis of HPA-1a alloimmunization in FNAIT and allosteric regulation of integrin conformation. [PDF]

Blood
Zhang H, Paddock C, Oosterhoff JJ, Nguyen HTT, Zhi H, Wang Z, Sheridan D, Stuge TB, Ghevaert C, Newman DK, Vidarsson G, Newman PJ, Zhu J.   +12 more
europepmc   +1 more source

Molecular mechanisms of transhydrogenase activity and allosteric regulation in eukaryotic type II PHGDH Ser33. [PDF]

Nat Commun
Perrone S, Cifuente JO, Mastrella L, Marina A, Marina A, Trastoy B, Becker-Kettern J, Conrotte JF, Alcaide-Jiménez A, Corzana F, Glaab E, Guerin ME, Linster CL.   +12 more
europepmc   +1 more source

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP. [PDF]

Nat Commun
Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I.   +7 more
europepmc   +1 more source

CryoEM structures reveal allosteric regulation of the catalytic activity of the multi-protein human MAT enzyme complexes. [PDF]

IUCrJ
Khaja FT, Vara R, Aspinall LP, Merriman C, Maerivoet A, White JBR, Muench SP, Hasnain SS, Antonyuk SV.   +8 more
europepmc   +1 more source

Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein. [PDF]

Nat Commun
Di Domenico V, Franceus J, Mastrella L, De Beul E, Alcaide-Jiménez A, Paredes-Martínez F, Villegas-Ruiz JC, Holden E, Rey AD, D'Angelo C, Cifuente JO, Struwe WB, Biondi RM, Marina A, Connell SR, Benesch JLP, Casino P, Colleoni C, Desmet T, Guerin ME.   +19 more
europepmc   +1 more source

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control. [PDF]

Protein Sci
Kim H, Feng S, Bohutskyi P, Li X, Mejia-Rodriguez D, Zhang T, Qian WJ, Cheung MS.   +7 more
europepmc   +1 more source

Allosteric regulation of kinase activity in living cells. [PDF]

Elife, 2023
Godbole SS, Dokholyan NV.
europepmc   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Human Transglutaminases: Updated Insights into Activation Mechanisms, Allosteric Regulation and Disease. [PDF]

Int J Mol Sci
Moya-Garrido P, Cano-Gómez LP, Ibarra-Molero B, Godoy-Ruiz R, Medina-Carmona E.   +4 more
europepmc   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source