Results 151 to 160 of about 11,653 (194)

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α. [PDF]

Angew Chem Int Ed Engl
Medina Gómez S, Homberg LT, Bührmann M, Rauh D, Linser R.   +4 more
europepmc   +1 more source

N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases. [PDF]

Sci Adv
Lee E, Redzic JS, Sarkar S, Rivkin D, Gordon B, Saviola AJ, Maroney SP, Thorstenson JC, Hansen KC, Horswill AR, Hamelberg D, Eisenmesser E.   +11 more
europepmc   +1 more source

Protein Allostery at Atomic Resolution

Angewandte Chemie - International Edition, 2020
Confined by the Boltzmann distribution of the energies of states, motion is inherent to biomolecules. For a detailed understanding of a protein’s function, not only the 3D structure but also the description of its dynamics is thus required.
Peter Güntert, Simon Olsson, Harindranath Kadavath   +2 more
exaly   +2 more sources

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Thrombin allostery

Physical Chemistry Chemical Physics, 2007
Thrombin is a Na(+)-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na(+) is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special ...
Enrico, Di Cera, Michael J, Page, Alaji, Bah, Leslie A, Bush-Pelc, Laura C, Garvey   +4 more
openaire   +2 more sources

ALLOSTERIE

EXERCER, 2021
À côté des travaux de recherche originaux, ce numéro d’exercer propose l’analyse commentée d’un récent article du Lancet, rédigée de main de maître par Denis Pouchain1.Curieusement, cette méta-analyse consacrée aux effets des traitements de l’hypertension artérielle n’a eu pour l’instant qu’un retentissement limité.
openaire   +1 more source

Protein topology and allostery

Current Opinion in Structural Biology, 2020
Allostery plays important roles in many biological processes. Although all non-fibrous proteins may be allosteric, currently only a limited number of allosteric proteins are known. How allosteric regulation depends on protein topology and what are the preferred folds in allosteric proteins need to be explored.
Juan, Xie, Luhua, Lai
openaire   +2 more sources

Hemoglobin allostery and pharmacology

Molecular Aspects of Medicine, 2022
The oxygen demands of the human body require the constant circulation of blood carrying an enormous concentration of hemoglobin (Hb). Oxygen transport depends not only on the amount of Hb, but also on the control over the affinity of the protein for the gas, which can be optimized for the environmental conditions by changes in the concentration of ...
Andrea Bellelli, Jeremy R.H. Tame
openaire   +2 more sources