Results 51 to 60 of about 18,737 (212)
Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG
mAbs, 2023 Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in ...
Andrew R. Crowley +5 more
doaj +1 more source
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. [PDF]
, 2018 Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR.
Ernst, Oliver P +11 more
core +2 more sources
Quarterly Reviews of BiophysicsAbstract Allostery describes the ability of biological macromolecules to transmit signals spatially through the molecule from an allosteric site – a site that is distinct from orthosteric binding sites of primary, endogenous ligands – to the functional or active site.
Mateu Montserrat-Canals +2 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2020 The allosteric effect is one of the most important processes in regulating the function of proteins, and the elucidation of this phenomenon plays a significant role in understanding emergent behaviors in biological regulation.
Giovanni Villani
doaj +1 more source
Architecture and Co-Evolution of Allosteric Materials
, 2016 We introduce a numerical scheme to evolve functional materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures and the correlations among them can be computed.
Brito, Carolina +3 more
core +1 more source
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]
, 2017 Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W +11 more
core +3 more sources
eLife, 2017 Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery.
Jing Li +9 more
doaj +1 more source
Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase
Nature Communications, 2023 Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery.
Federica Maschietto +10 more
doaj +1 more source
iScience, 2021 Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer ...
Ravi Jasuja +10 more
doaj +1 more source
Coarse-grained model of entropic allostery [PDF]
, 2004 Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via
A. Cooper +13 more
core +3 more sources