Results 71 to 80 of about 2,433,880 (389)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Hot Extrusion Enhanced Homogenization of Microstructure in a Spray Deposition Aluminum Alloy

open access: yesMetals, 2020
Homogeneous heat treatment serves the significant roles in eliminating the segregation and tuning the microstructure of alloy ingot. It usually cost tremendous power and time to achieve a homogeneous microstructure for aluminum alloys.
Xiaofei Sheng   +7 more
doaj   +1 more source

Materials data handbook, aluminum alloy 6061 [PDF]

open access: yes, 1969
Comprehensive compilation of technical data on aluminum alloy 6061 is presented in handbook form. The text includes data on the properties of the alloy at cryogenic, ambient, and elevated temperatures and other pertinent information required for the ...
Sessler, J., Weiss, V.
core   +1 more source

Effect of nickel on the microstructure and mechanical property of die-cast Al–Mg–Si–Mn alloy [PDF]

open access: yes, 2014
The effect of nickel on the microstructure and mechanical properties of a die-cast Al–Mg–Si–Mn alloy has been investigated. The results show that the presence of Ni in the alloy promotes the formation of Ni-rich intermetallics.
A Santini   +26 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

High temperature alloy [PDF]

open access: yes, 1968
Molybdenum is substituted for tungsten on an atomic basis in a cobalt-based alloy, S-1, thus enabling the alloy to be formed into various mill products, such as tubing and steels.
Frank, R. G., Semmel, J. W., Jr.
core   +1 more source

A strong and ductile medium-entropy alloy resists hydrogen embrittlement and corrosion

open access: yesNature Communications, 2020
Strong and ductile materials that have high resistance to corrosion and hydrogen embrittlement are rare and yet essential for realizing safety-critical energy infrastructures, hydrogen-based industries, and transportation solutions. Here we report how we
Hong Luo   +8 more
semanticscholar   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Heat treatment study of aluminum casting alloy M45 [PDF]

open access: yes, 1967
Study determines the heat treatment cycle of aluminum casting alloy M-45 which will increase the strength levels of the alloy while maintaining optimum stress corrosion resistance.
Lovoy, C. V.
core   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

open access: yesFEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada   +3 more
wiley   +1 more source

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