Results 61 to 70 of about 889,141 (311)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Effect of Heating Rate on Creep Aging Behavior of 2219 Aluminum Alloy
Cailiao gongcheng, 2018 Effect of heating rate on creep aging behavior and mechanical properties in the process of creep aging forming of 2219 aluminum alloy was studied. In order to simulate the temperature conditions of the component in autoclave, heating rate was reduced to ...
LIU Ling-feng, ZHAN Li-hua, LI Wen-ke
doaj +1 more source
Materials data handbook, Inconel alloy 718 [PDF]
, 1967 Materials data handbook on Inconel alloy 718 includes data on the properties of the alloy at cryogenic, ambient, and elevated temperatures and other pertinent engineering information required for the design and fabrication of components and equipment ...
Sessler, J., Weiss, V.
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Metals, 2018 To study the factors that affect the mechanical properties of materials, double-pass hot compression tests were performed under different deformation parameters using a Gleeble-3500 thermo-simulation machine.
Changqing Huang +2 more
doaj +1 more source
Heat treatment study of aluminum casting alloy M45 [PDF]
, 1967 Study determines the heat treatment cycle of aluminum casting alloy M-45 which will increase the strength levels of the alloy while maintaining optimum stress corrosion resistance.
Lovoy, C. V.
core +1 more source
Influence of oxide films on primary water stress corrosion cracking initiation of alloy 600 [PDF]
, 2006 In the present study alloy 600 was tested in simulated pressurised water reactor (PWR) primary water, at 360 °C, under an hydrogen partial pressure of 30 kPa. These testing conditions correspond to the maximum sensitivity of alloy 600 to crack initiation.
Andrieu, Eric +5 more
core +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source