De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase
Plant Biotechnology Journal, EarlyView.ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He +7 more
wiley +1 more source
Copper-Catalyzed Diastereoselective Defluoroborylation of Pentafluoroethyl Alkenes Using (pin)B-B(dan). [PDF]
Org LettTang Y, Tsui GC.
europepmc +1 more source
Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva +9 more
wiley +1 more source
New Mannich-type arylidenerhodanines as potent inhibitors of AChE and BChE: synthesis, biological evaluation, cytotoxicity and molecular modeling. [PDF]
RSC AdvSinan Tokalı F +5 more
europepmc +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
50 Years of Giese Reaction – a Personal View
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.The Giese‐Reaction celebrates its 50. Birthday, it is a cyclic radical chain reaction centered around C,C‐bond formation in a three component synthesis. This minireview speaks about the birth of the name‐reaction, explains how the complete understanding of its reaction mechanism stimulates new methods in organic synthesis, and why it can proceed in ...
Martin Spichty +4 more
wiley +2 more sources
Postharvest Application of Black Mustard (<i>Brassica nigra</i>) Seed Derivatives in Sweet Cherry Packaging for Rot Control. [PDF]
FoodsCalvo P +3 more
europepmc +1 more source
Band‐Selective IR PRESS for Brain Tumor Spectroscopy Allows Robust Detection of Lactate
NMR in Biomedicine, Volume 39, Issue 3, March 2026.Lactate quantification by MRS is hindered by lipid signal overlap at 1.3 ppm, frequently forcing the use of long echo times that suppress other metabolites. We developed SPIR‐PRESS, a selective inversion recovery technique that suppresses lipids while preserving metabolite sensitivity.
Shun Kishimoto +12 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.A complexity‐generating intramolecular alkene diamination constitutes the pivotal step in the enantioselective synthesis of the title natural products featuring a strained, cage‐like pentacyclic architecture. Abstract Among more than four thousand monoterpene indole alkaloids (MIAs) isolated to date, only a few feature a 2,2,3‐trisubstituted indoline ...
Vincent Goëlo, Qian Wang, Jieping Zhu
wiley +2 more sources
Tracing the Path from Obesity to Diabetes: How S-Allyl Cysteine Shapes Metabolic Health. [PDF]
NutrientsGeddo F +3 more
europepmc +1 more source