Results 221 to 230 of about 62,639 (299)

Catalytic asymmetric tandem Heck/Sonogashira reaction enabling access to versatile chiral bridged ring scaffolds. [PDF]

Nat Commun
Zhong J, Li M, Wu C, Li H, Dong H, Che C, Lin A, Yao H.   +7 more
europepmc   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Divergent Synthesis of Homoallylic and Allenic Sulfides, Selenides, and S,C-Sulfonium Ylides by Ruthenium Catalysis. [PDF]

Precis Chem
He Z, Wu L, Ma Y, Wen L, Liu X, Ding W, Hu W, Wu X.   +7 more
europepmc   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Curcumin-Based Tri-Allyl Derivative for Bismaleimide Resins: Synergistic Modulation of Thermal Stability and Fire Safety. [PDF]

Polymers (Basel)
Liu H, Olszewska T, Liu H.
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Formal Diels-Alder reaction of saturated carboxylic acids via C-H activation. [PDF]

Nat Chem
He Q, Lu Y, Sheng T, Chekshin N, Yan JL, Zhang T, Yu JQ.   +6 more
europepmc   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source

In Silico Design, Synthesis, and Antibacterial Evaluation of Allyl Esters of Salicylic and Acetylsalicylic Acid and Their Copolymers. [PDF]

Molecules
Garaev E, Rasulov N, Aliyeva S, Yusifova J.   +3 more
europepmc   +1 more source

Decadal Rapid Change in Energetic Carrying Capacity for Juvenile Chum Salmon in the Sanriku Coast

Fisheries Oceanography, EarlyView.
ABSTRACT Adult returns to coastal rivers in Sanriku, located near the southernmost area of chum salmon distribution, have declined since 2010. Climate‐induced fluctuations in juvenile prey availability may affect growth and survival, which are linked to adult returns.
Yuki Iino, Yuichi Shimizu, Tomoki Sato, Takashi Kitagawa   +3 more
wiley   +1 more source