Results 41 to 50 of about 1,062,122 (246)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
On almost λ- statistical convergence of fuzzy numbers - doi: 10.4025/actascitechnol.v36i1.16218
Acta Scientiarum: Technology, 2014 The purpose of this paper is to introduce the concepts of almost λ-statistical convergence and strongly almost λ- convergence of fuzzy numbers. We obtain some results related to these concepts.
Ayhan Esi, Mehmet Acikgoz
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Applications of Complex Uncertain Sequences via Lacunary Almost Statistical Convergence
AxiomsWe explore the realm of uncertainty theory by investigating diverse notions of convergence and statistical convergence concerning complex uncertain sequences.
Xiu-Liang Qiu +5 more
doaj +1 more source
IET Control Theory & Applications, 2021 Stochastic gradient descent algorithm is a classical and useful method for stochastic optimisation. While stochastic gradient descent has been theoretically investigated for decades and successfully applied in machine learning such as training of deep ...
Xiaoxue Geng, Gao Huang, Wenxiao Zhao
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Strongly almost summable sequences of order a
Kuwait Journal of Science, 2014 In this paper, we introduce the concept statistical convergence of order . Also some relations between -statistical convergence of order and strong -summability of order are given. Furthermore some relations between the spaces and are examined.
MİKAİL ET, RİFAT ÇOLAK, YAVUZ ALTIN
doaj
Almost-everywhere convergence and polynomials
Journal of Modern Dynamics, 2008 6 ...
Boshernitzan, Michael, Wierdl, Mate
openaire +2 more sources