Results 81 to 90 of about 6,768,037 (271)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
, 2008 Quite recently Bor [H. Bor, An application of almost increasing and delta-quasi-monotone sequences, JIPAM. J. Inequal. Pure Appl. Math. 1 (2) (2000).
Savaş, Ekrem
core +1 more source
Frontiers in Microbiology, 2019 Exploring the characteristics of the HIV-1 envelope glycoprotein (env) gene in a natural HIV-1 infected individual, with broadly neutralizing activity, may provide insight into the generation of such broadly neutralizing antibodies and initiate the ...
Dai Zhang +10 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
An almost sure conditional convergence result and an application to a generalized Polya urn [PDF]
, 2009 We prove an almost sure conditional convergence result toward a Gaussian kernel and we apply it to a two-colors randomly reinforced ...
Crimaldi, I, Crimaldi, Irene
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Almost perfect sequences with θ=2
, 1998 Almost perfect sequences with θ=2 are studied in this paper. Recently Arasu, Ma and Voss [1] studied such sequences and they could only obtain sequences having periods 8, 12 and 28. In this paper, we prove that no other almost perfect sequences exist for
Ma, Siu Lun +3 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2023 Fasta files from references and generated sequences:excluded sequences = positive controls (already deposited sequences) and sequences below 50% length coveragesequences_for_submission = sequences with no gaps
Nadja Brait (17379988)
core +1 more source