Results 111 to 120 of about 1,903,470 (246)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

On the relationship of Cm $C^{m}$-almost periodicity on R $\mathbb {R}$ and time scales

Advances in Difference Equations, 2018
In this paper, we improve the concept of Cm $C^{m}$-almost periodicity on periodic time scales. The concept is based on the revised definition of almost periodicity introduced by Wang and Agarwal in 2015.
Yan Wang
doaj   +1 more source

Almost periodicity and discrete almost periodicity in semiflows

Mathematical Communications, 2011
A theory of semiflows with a discrete acting topological semigroup was developed in the 2000 paper by D. Ellis, R. Ellis and M. Nerurkar ([2]). A theory for the case of an arbitrary acting topological semigroup has still to be developed. This paper can be considered as the beginning of an attempt in that direction.
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

On detecting and modeling periodic correlation in financial data [PDF]

For many economic problems standard statistical analysis, based on the notion of stationarity, is not adequate. These include modeling seasonal decisions of consumers, forecasting business cycles and - as we show in the present article - modeling ...
Rafal Weron, Andrzej Makagon, Agnieszka Wylomanska, Ewa Broszkiewicz-Suwaj   +3 more
core  

Almost-periodic solution for BAM neural networks [PDF]

Surveys in Mathematics and its Applications, 2009
In this paper, we study the existence and uniqueness solution and investigate the conditions that make it almost-periodic solution for BAM neural networks with retarded delays.
Hamid A. Jalab, Rabha W. Ibrahim
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Almost automorphic and pseudo almost periodic solutions to damped Euler–Lagrange equations

Examples and Counterexamples
This paper investigates the existence of almost automorphic, asymptotically almost automorphic, pseudo almost automorphic, and pseudo almost periodic solutions to damped Euler–Lagrange equations.
Bouadi Abdelkader, Boudjema Souhila, Houmia Anouar   +2 more
doaj   +1 more source

Almost Periodic Solutions for Some Convolution Equations

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013
We use the theory of Fourier series for almost periodic functions to looking for complex-valued functions f which are almost periodic on R and satisfy the following ...
Corduneanu Silvia-Otilia
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source