Results 91 to 100 of about 1,903,470 (246)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Duality properties and Riesz representation theorem in Besicovitch-Musielak-Orlicz space of almost periodic functions [PDF]

open access: yes, 2000
summary:This paper is an extension of the work done in [Morsli M., Bedouhene F., Boulahia F., Duality properties and Riesz representation theorem in the Besicovitch-Orlicz space of almost periodic functions, Comment. Math. Univ. Carolin. 43 (2002), no. 1,
Daoui, A.   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Time-domain harmonic balance method for aerodynamic and aeroelastic simulations of turbomachinery flows [PDF]

open access: yes, 2013
A time-domain Harmonic Balance method is applied to simulate the blade row interactions and vibrations of state- of-the-art industrial turbomachinery configurations. The present harmonic balance approach is a time-integration scheme that turns a periodic
Dufour, Guillaume   +2 more
core   +1 more source

Equi-asymptotically almost periodic functions and applications to functional integral equations

open access: yesElectronic Journal of Differential Equations, 2013
In this article, we introduce the notion of equi-asymptotically almost periodicity, and investigate some properties of equi-asymptotically almost periodic functions. In addition, by applying the results on equi-asymptotically almost periodic functions,
Hui-Sheng Ding   +2 more
doaj  

Characterizations of vector-valued weakly almost periodic functions

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2003
We characterize the weak almost periodicity of a vector-valued, bounded, continuous function. We show that if the range of the function is relatively weakly compact, then the relative weak compactness of its right orbit is equivalent to that of its left ...
Chuanyi Zhang
doaj   +1 more source

Almost periodic solutions of Volterra difference systems

open access: yesDemonstratio Mathematica, 2017
We study the existence of an almost periodic solution of discrete Volterra systems by means of fixed point theory. Using discrete variant of exponential dichotomy, we provide sufficient conditions for the existence of an almost periodic solution.
Koyuncuoglu Halis Can, Adıvar Murat
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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