Results 61 to 70 of about 554,389 (270)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2002 We prove that the evolution semigroup on $AAP_0(mathbb{R}_+, X)$ is strongly continuous. Then we prove some properties of the generator of this evolution semigroup and show some applications in the theory of inequalities.
Constantin Buse
doaj
Completely almost periodic functionals [PDF]
Archiv der Mathematik, 2011 8 pages; some ...
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
The Space of Continuous Periodic Functions Is a Set of First Category in AP(X)
Journal of Function Spaces and Applications, 2013 We prove that the space of continuous periodic functions is a set of first category in the space of almost periodic functions, and we also show that the space of almost periodic functions is a set of first category in the space of almost automorphic ...
Zhe-Ming Zheng +2 more
doaj +1 more source
Almost Periodic Functions in Groups
Hiroshima Mathematical Journal, 1941 Not ...
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
(ω, c)- Pseudo almost periodic distributions
Nonautonomous Dynamical Systems, 2020 The paper is a study of the (w, c) −pseudo almost periodicity in the setting of Sobolev-Schwartz distributions. We introduce the space of (w, c) −pseudo almost periodic distributions and give their principal properties.
Khalladi Mohammed Taha +1 more
doaj +1 more source