Results 21 to 30 of about 9,441 (247)

Almost sure convergence of extreme order statistics

Electronic Journal of Statistics, 2009
Let $M_n^{(k)}$ denote the $k$th largest maximum of a sample $(X_1,X_2,...,X_n)$ from parent $X$ with continuous distribution. Assume there exist normalizing constants $a_n>0$, $b_n\in \mathbb{R}$ and a nondegenerate distribution $G$ such that $a_n^{-1}(M_n^{(1)}-b_n)\stackrel{w}{\to}G$.
Peng, Zuoxiang, Li, Jiaona, Nadarajah, Saralees   +2 more
openaire   +4 more sources

On the almost sure convergence of weighted sums of random elements in D[0,1]

International Journal of Mathematics and Mathematical Sciences, 1981
Let {wn} be a sequence of positive constants and Wn=w1+…+wn where Wn→∞ and wn/Wn→∞. Let {Wn} be a sequence of independent random elements in D[0,1]. The almost sure convergence of Wn−1∑k=1nwkXk is established under certain integral conditions and growth ...
R. L. Taylor, C. A. Calhoun
doaj   +1 more source

Cooling down stochastic differential equations: Almost sure convergence

Stochastic Processes and their Applications, 2022
We consider almost sure convergence of the SDE $dX_t=α_t d t + β_t d W_t$ under the existence of a $C^2$-Lyapunov function $F:\mathbb R^d \to \mathbb R$. More explicitly, we show that on the event that the process stays local we have almost sure convergence in the Lyapunov function $(F(X_t))$ as well as $\nabla F(X_t)\to 0$, if $|β_t|=\mathcal O( t^{-β}
Dereich, Steffen, Kassing, Sebastian
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Almost Sure and Lp Convergence of Split-Step Backward Euler Method for Stochastic Delay Differential Equation

Abstract and Applied Analysis, 2014
The convergence of the split-step backward Euler (SSBE) method applied to stochastic differential equation with variable delay is proven in Lp-sense.
Qian Guo, Xueyin Tao
doaj   +1 more source

On almost sure convergence rates for the kernel estimator of a covariance operator under negative association [PDF]

Journal of Mahani Mathematical Research
It is suppose that $\{X_n,~n\geq 1\}$ is a strictly stationary sequence of negatively associated random variables with continuous distribution function F.
Hadi Jabbari
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source