Results 101 to 110 of about 3,214 (198)

Release of VEGF from dental implant improves osteogenetic process: Preliminary in vitro tests [PDF]

, 2017
INTRODUCTION: During osseointegration process, the presence of an inflammatory event could negatively influence the proper osteogenetic ability of the implant surface.
Ferroni, Letizia, Gardin, Chiara, Mijiritsky, Eitan, Piattelli, Adriano, Sivolella, Stefano, Zavan, Barbara   +5 more
core   +2 more sources

Whole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non‐Small Cell Lung Cancers

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Epidermal growth factor receptor (EGFR)‐mutated lung adenocarcinoma (LUAD) is the most common subtype among non‐small cell lung cancer (NSCLC) and targeted therapies are the primary approach for treatment. However, the development of resistance to therapy and histological transformation into small cell lung cancer (SCLC) present ...
Jinjing Tan, Dan Zhao, Qunhui Wang, Yanjing Peng, Jie Li, Xi Li, Nanying Che, Ying Hu, Hua Zheng   +8 more
wiley   +1 more source

Whole genome sequencing identifies a novel ALMS1 gene mutation in two Chinese siblings with Alström syndrome

BMC Medical Genetics, 2017
Background Alström syndrome is a rare multi-systemic disorder with a broad spectrum of symptoms. This syndrome is characterized by childhood retinal degeneration; sensorineural hearing loss; obesity; type 2 diabetes mellitus; cardiomyopathy; systemic ...
Lin Yang, Zixiu Li, Mei Mei, Xiaomei Fan, Guodong Zhan, Huijun Wang, Guoying Huang, Mingbang Wang, Weidong Tian, Wenhao Zhou   +9 more
doaj   +1 more source

Ocular evaluation and genetic test for an early Alström Syndrome diagnosis

American Journal of Ophthalmology Case Reports, 2020
Purpose: We present 3 cases of Alström syndrome (ALMS) that highlight the importance of the ophthalmic exam, as well as the diagnostic challenges and management considerations of this ultra-rare disease.
Tyler Etheridge, Elizabeth R. Kellom, Rachel Sullivan, James N. Ver Hoeve, Melanie A. Schmitt   +4 more
doaj   +1 more source

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice

Biochemical and Biophysical Research Communications, 2006
The biochemical differences between simple steatosis, a benign liver disease, and non-alcoholic steatohepatitis, which leads to cirrhosis, are unclear. Fat aussie is an obese mouse strain with a truncating mutation (foz) in the Alms1 gene. Chow-fed female foz/foz mice develop obesity, diabetes, and simple steatosis.
Arsov, Todor, Larter, Claire, Nolan, Christopher, Petrovsky, Nikolai, Goodnow, Christopher, Teoh, Narcissus, Yeh, Matthew, Farrell, Geoffrey   +7 more
openaire   +3 more sources

Long term exposure to a butter rich diet induces mild-to-moderate steatosis in Chang liver cells and swiss albino mice models [PDF]

, 2017
Background:Butter is one of the widely used fats present in the diet. However, there is no satisfactory study available that evaluates the effect of a high-fat diet containing butter as the principal fat on the development of non-alcoholic fatty liver ...
Kumar, Nitesh, Nalloor, Thomas John Philip, Narayanan, Kasinathan, Palanimuthu, Vasanth Raj   +3 more
core   +1 more source

MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives

Molecular Oncology, Volume 19, Issue 2, Page 275-294, February 2025.
Metabolic dysfunction‐associated steatohepatitis is emerging as a leading cause of hepatocellular carcinoma in individuals whose lifestyle and dietary habits promote a positive energy balance. Here, we reviewed the role of free fatty acids in mediating lipotoxicity and its implications for organellar stress and genome alteration in hepatocytes ...
Michael Karin, Ju Youn Kim
wiley   +1 more source

Unveiling the Genetic and Phenotypic Landscape of a Chinese Cohort With Retinitis Pigmentosa

Molecular Genetics &Genomic Medicine, Volume 13, Issue 2, February 2025.
Our study conducted a genetic analysis of a cohort of 69 Chinese RP patients from 36 families. Genetic and phenotypic landscapes of this cohort were performed. Furthermore, three novel variants were identified in this study, and the high frequency variant (NM_001034853.1: c.2236_2237del) of RPGR detected from a big pedigree was discussed in detail ...
He‐nan Sun, Kai‐li Du, Yan Sun, Cong Liu, Jin‐hui Xue, Xin‐xin Wang, Ye liu, Hui‐hui Yu, Jia‐yuan Ge, Jia Rong, Di Wang, Yue Ren, Ji‐jing Pang, Jian‐Kang Li, Zhuo‐Shi Wang   +14 more
wiley   +1 more source

Identification and Validation of a m6A‐Related Long Noncoding RNA Prognostic Model in Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 2, January 2025.
ABSTRACT Accumulating research indicates that N6‐methyladenosine (m6A) modification plays a pivotal role in colorectal cancer (CRC). Hence, investigating the m6A‐related long noncoding RNAs (lncRNAs) significantly improves therapeutic strategies and prognostic assessments. This study aimed to develop and validate a prognostic model based on m6A‐related
Peng Jiang, Mingfei Chu, Yu Liang
wiley   +1 more source

A novel homozygous ALMS1 protein truncationmutation (c.2938dupA) revealed variable clinicalexpression among Saudi Alström syndrome patients [PDF]

, 2020
Amnah Y. Bdier, Faten Alqahtani, Prashant Kumar Verma, Naeem Alshoaibi, Nuha Mohammed Alrayes, Noor Ahmad Shaik, Roger Foo, Zahurul A. Bhuiyan, Jumana Y. Al‐Aama   +8 more
openalex   +1 more source