as is usual in DDD, an increasednumber ofmelanocytes was not found in our patient, unlike the patient of Kameyama et aI. Kameyama and co-workers suggest that azelaic acid more easily penetrates active melanocytes; perhaps in our patient the melanocyteswere in a less active state.
Karla Werninghaus, Michael S. Kaminer
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Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement after Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies [PDF]
Scalp psoriasis with alopecia is a rare cutaneous reaction to tumor necrosis factor alpha antagonists. This reaction often reverses with discontinuation of the offending drug and initiation of topical treatments; however, irreversible hair loss may occur
Jeremy Udkoff, Philip R. Cohen
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Chromosomal assignment of the ovine hairless (hr) gene by fluorescence in situ hybridization. [PDF]
Congenital hypotrichosis in mammalian species consists of partial or complete absence of a hair coat at birth. Affected individuals having a partial hair coat at birth may loose it subsequently.The aim of this paper was to physically map the ovine hr
Budelli E +6 more
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Alopecia Universalis Successfully Treated With Adalimumab [PDF]
IMPORTANCE Alopecia universalis is an uncommon form of alopecia areata (AA) involving hair loss over the entire scalp and body and is often difficult to treat. Tumor necrosis factor (TNF)inhibitors have been largely unsuccessful in treating AA and have been reported to induce or worsen AA in patients.We report herein a case of alopecia universalis ...
Loren, Gorcey +2 more
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Computer-guided concentration-controlled trials in autoimmune disorders [PDF]
A randomized concentration-controlled clinical trial (RCCCT) is an alternate experimental design to the standard dose-controlled study. In a RCCCT, patients are randomly assigned to predefined plasma or blood drug concentration ranges (low, medium, and ...
Doyle, H +7 more
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Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs
Gkoutos, Georgios V +2 more
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AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS):partial gene deletions contribute to APS I [PDF]
Udgivelsesdato: MarAutoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear ...
Bruland, O +8 more
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Alopecia areata – Current understanding and management [PDF]
Alopecia areata (AA) is a chronic, immune-mediated disease characterized by acute or chronic non-scarring hair loss, with a heterogeneity in clinical manifestations ranging from patchy hair loss to complete scalp and body hair loss. An overview of the up-
Blume‐Peytavi, Ulrike +5 more
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Effect of hairless gene polymorphism on the breeding values of milk production traits in Valle del Belice sheep [PDF]
The aim of this work was to assess the association between the hairless genotypes and estimated breeding values (EBVs) for milk yield (MY), fat (FAT) and protein (PRT) content in Valle del Belice dairy sheep breed.
MASTRANGELO, Salvatore +3 more
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Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata. [PDF]
Alopecia areata (AA), an autoimmune disease affecting anagen stage hair follicles, is associated with polymorphisms in immune-related genes and with decreased number of CD4+ CD25+ T regulatory cells (Treg).
Conteduca, Giuseppina
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