Results 91 to 100 of about 30,547,503 (170)
Generation and characterisation of transgenic zebrafish expressing human alpha-1-antitrypsin
, 2017 The Z variant of α1-antitrypsin (Z-AAT) is the most common “severe” deficiency allele of α1-antitrypsin. It affects approximately 2% to 5% of Caucasians of European descent [1-3].
Yip, Evelyn Lai Si (3770644)
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Variants of alpha-1-antitrypsin
, 2023 Provided are variants of alpha-1-antitrypsin comprising mutations which render the variants oxidation- as well as protease-resistant, polynucleotides encoding said variants, methods of producing the variants and the variants for use in the treatment of ...
Schoffelen, Sanne +2 more
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Alpha-1-antitrypsin deficiency
, 2021 The subject of this review is alpha-1-antitrypsin deficiency (A1AD), which is a rare hereditary disease with great impact in adults, especially smokers, quality of life and longevity. Early diagnosis is crucial for treatment outcome.
Jensen, Jens-Ulrik +5 more
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Alpha-1 antitrypsin phenotypes and alcoholic pancreatitis
, 1991 Altered frequencies of alpha-1 antitrypsin phenotypes have been reported in patients with chronic pancreatitis, suggesting a possible genetic basis for individual susceptibility to this disease.
Pirola, R. C. +5 more
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Alpha-1-antitrypsin replacement therapy: current status
, 2006 PURPOSE OF REVIEW: Alpha-1-antitrypsin deficiency is a relatively common genetic disease that predisposes to the development of early-onset emphysema and, in some instances, liver disease.
Hatem Abusriwil +3 more
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, 2015 Sanjay H Chotirmall,1 Mazen Al-Alawi,2 Thomas McEnery,2 Noel G McElvaney2 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Respiratory Medicine, Beaumont Hospital, Dublin, Republic of Ireland Abstract ...
Chotirmall SH +3 more
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Vascular Pathology in Alpha 1 Antitrypsin Deficient Chronic Obstructive Pulmonary Disease and Emphysema Patients: Case Reports [PDF]
Matthew Gordon,1,* Andrew J Gangemi,1,* Eric L Sandwith,2,* Maruti Kumaran,3,* Friedrich Kueppers1,* 1Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA; 2HCA Florida
Gordon M +4 more
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Exploration of Mutations of Alpha-1-Antitrypsin [PDF]
, 2018 Alpha-1-Antitrypsin is a protein that functions as a protease inhibitor specifically for neutrophil elastase, an enzyme which breaks down elastin in the lungs.
Sanders, Robby, Edwards, Shelley
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Is It Time Alpha-1 Antitrypsin Deficiency Had a Specific Patient Reported Outcome Measure? A Review [PDF]
Joshua De Soyza, Hung-Yeh Chien, Adeola Ayodotun Onasanya, Alice M Turner Institute of Applied Health Sciences, University of Birmingham, Birmingham, UKCorrespondence: Joshua De Soyza, Email j.desoyza@bham.ac.ukAbstract: Alpha-1 antitrypsin deficiency ...
Chien HY +3 more
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Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review
, 2017 Ross G Edgar,1,2 Mitesh Patel,3 Susan Bayliss,4 Diana Crossley,2,5 Elizabeth Sapey,2,5 Alice M Turner4,6 1Therapy Services, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 2Institute of Inflammation and Ageing, University of ...
Edgar RG +5 more
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