Results 121 to 130 of about 36,766 (231)

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Classical mucocuaneous triad of dyskeratosis congenita in a patient with decompensated cirrhosis. ABSTRACT Dyskeratosis congenita (DC) is a genetic disorder characterized by multisystem involvement. The most commonly affected systems are the mucocutaneous, bone marrow, and lungs.
Bigyan Maharjan, Pradeep Neupane, Bikash Poudel, Ramesh Jha, Suraj Subedi, Jessica Baral, Abhishek Pandit, Shraddha Uprety, Mukesh Kumar Ranjan   +8 more
wiley   +1 more source

Estimates of the Prevalence and Number of Fibromyalgia Syndrome Patients and Their Alpha-1 Antitrypsin Phenotypic Distributionin Ten Countries [PDF]

, 2009
During the last few years, clinical, epidemiological, and pathological evidence has suggested that inherited alpha-1 antitrypsin [AAT] deficiency might play a role in the development of the fibromyalgia syndrome [FMS], probably because of the loss of AAT
Arbesú, Daniel, Astudillo, Aurora, Blanco, Ignacio, Cárcaba, Victoriano, Fernández, Enrique, Janciauskiene, Sabina, Nita, Izabela, Serres, F.J. (Frederick)   +7 more
core  

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

Tissue‐Derived Extracellular Vesicles Define Diagnostic Biomarkers for Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Tissue‐derived EVs reveal renal cell carcinoma subtype biomarkers (NDUFA4L2/VEGFA/APOC1). Validated in urinary EVs (AUC 0.92), these markers originate from cancer cells and tumour‐associated macrophages via scRNA‐seq, enabling non‐invasive diagnosis and mechanistic insights into RCC progression.
Xinrui Wu, Jiale Zhou, Chen Jiang, Wenjin Chen, Zehong Peng, Tianyang Wu, Yang Ge, Xinxing Du, Cong Hu, Xiaorong Wu, Jiwei Huang, Jin Zhang, Xingang Cui, Wei Xue, Yonghui Chen, Liang Dong   +15 more
wiley   +1 more source

Clinical presentation, treatment, and outcome of children with primary intestinal lymphangiectasia: A national retrospective study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 398-406, February 2026.
Abstract Objectives Primary intestinal lymphangiectasia (PIL) is a very rare disease responsible for protein‐losing enteropathy. There is little published data about treatments efficacy and outcomes. Our main objective was to describe the clinical profile, response to therapy, and outcomes of children with PIL.
Noémie Goret, Cécile Lambe, Emmanuelle Ecochard‐Dugelay, Alexandre Fabre, Alain Dabadie, Aurélie Comte, Julie Rebeuh, Pierre Poinsot, Emilie Chaillou, Haude Clouzeau, Aurélie Sabard, Béatrice Dubern, Stéphanie Willot   +12 more
wiley   +1 more source

Deficiência de alfa-1-antitripsina na doença pulmonar obstrutiva crónica [PDF]

, 2009
Introdução – A deficiência de alfa-1-antitripsina é uma das alterações genéticas graves encontradas por todo o mundo. Porém, permanece subdiagnosticada, apesar da forte predisposição à doença pulmonar obstrutiva crónica que condiciona.
Cardoso, Patrícia Neves
core  

Alpha 1-Antitrypsin-Labor und Alpha 1-Antitrypsin-Register [PDF]

Pneumologie, 2004
R. Bals, C. Vogelmeier
openaire   +1 more source

DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report

JPGN Reports, Volume 7, Issue 1, Page 11-13, February 2026.
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive primary immunodeficiency. Patients with DOCK8 deficiency typically present at early age with allergic manifestations, cutaneous and respiratory infections, raised immunoglobulin E, and they have an increased risk of developing malignancies.
Natalia Nedelkopoulou, Kelechi Ugonna, Stephen Hughes, Sanjay Rajwal, Marumbo Mtegha   +4 more
wiley   +1 more source

Long-term augmentation therapy with Alpha-1 Antitrypsin in an MZ-AAT severe persistent asthma [PDF]

, 2010
A young Caucasian female with severe bronchial asthma and Alpha1-antitrypsin (AAT) deficiency, MZ phenotype, experienced a quick and severe limitation of her physical capacity, which negatively affected her psychological state and social life, though she
Blanco, Ignacio, Bustillo, E.F. (E.), Camblor, C., Canto, H., Cárcaba, Victoriano, Flóres, J., Janciauskiene, Sabina, Serres, F.J. (Frederick)   +7 more
core