Results 31 to 40 of about 107,093 (255)
Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD
Multidisciplinary Respiratory Medicine, 2017 Background Alpha-1-antitrypsin deficiency (AATD) is an under-diagnosed condition in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to screen for AATD in Kazakh patients with COPD using dried blood spot specimens ...
Ardak Zhumagaliyeva +12 more
doaj +1 more source
Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know
Therapeutic Advances in Chronic Disease, 2021 Management of lung disease in patients with alpha-1 antitrypsin deficiency (AATD) includes both non-pharmacological and pharmacological approaches. Lifestyle changes with avoidance of environmental pollutants, including tobacco smoke, improving exercise ...
I. Barjaktarevic, Michael A Campos
semanticscholar +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Alpha-1 antitrypsin deficiency: clarifying the role of the putative protective threshold
European Respiratory Journal, 2021 Alpha-1 antitrypsin deficiency (AATD) is the only readily identifiable monogenic cause of COPD. To date the only condition-specific treatment for AATD-associated COPD is weekly administration of intravenous plasma-purified human alpha-1 antitrypsin (IV ...
A. Franciosi +3 more
semanticscholar +1 more source
Update on and future perspectives for the diagnosis of alpha-1 antitrypsin deficiency in Brazil
Jornal Brasileiro de Pneumologia, 2021 Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder caused by a mutation in the SERPINA1 gene, which encodes the protease inhibitor alpha-1 antitrypsin (AAT). Severe AATD predisposes individuals to COPD and liver disease.
José R Jardim +5 more
doaj +2 more sources
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease
International Journal of Molecular Sciences, 2021 Alpha-1 antitrypsin deficiency (AATD) is caused by a single mutation in the SERPINA1 gene, which culminates in the accumulation of misfolded alpha-1 antitrypsin (ZAAT) within the endoplasmic reticulum (ER) of hepatocytes.
N. Khodayari +9 more
semanticscholar +1 more source
Alpha-1 antitrypsin deficiency gut microbiome
, 2020 This dataset contains 16S rRNA Illumina MiSeq sequenced samples used in our gut microbiome study in individuals with alpha-1 antitrypsin deficiency (AATD) and controls (non-AATD)
Kirst, ME (University of Florida)
core +1 more source
Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice
JCI Insight, 2021 Alpha-1 antitrypsin (AAT) is a major inhibitor of serine proteases in mammals. Therefore, its deficiency leads to protease–antiprotease imbalance and a risk for developing lung emphysema.
L. Ostermann +10 more
semanticscholar +1 more source
GE: Portuguese Journal of Gastroenterology, 2023 Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic diseases and is caused by mutations in the SERPINA1 gene. The homozygous Pi*Z variant is responsible for the majority of the classic severe form of alpha-1 antitrypsin deficiency ...
Nélia Abreu +3 more
doaj +1 more source
Severe alpha‐1‐antitrypsin deficiency increases the risk of venous thromboembolism
Journal of Thrombosis and Haemostasis, 2021 Severe alpha‐1‐antitrypsin deficiency (AATD), phenotype PiZZ, is associated with increased risk of liver disease and chronic obstructive pulmonary disease (COPD), but the risk of venous thromboembolism (VTE) is unknown.
Nawfal Basil +6 more
semanticscholar +1 more source