Results 101 to 110 of about 30,248,737 (228)
Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major cause of cancer‐related mortality worldwide. Its poor clinical outcomes are largely attributed to late‐stage diagnosis and the limited accuracy of currently available diagnostic and prognostic biomarkers.
Jana Hamad +2 more
wiley +1 more source
Variants of alpha-1-antitrypsin
, 2023 Provided are variants of alpha-1-antitrypsin comprising mutations which render the variants oxidation- as well as protease-resistant, polynucleotides encoding said variants, methods of producing the variants and the variants for use in the treatment of ...
Schoffelen, Sanne +2 more
core
Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Major Depressive Disorder (MDD) is a highly common neuropsychiatric disorder globally. A variety of factors contribute to the neuropathology of MDD. Microbiome research in neuropsychiatric disorders such as MDD has recently attracted attention. Indeed, the gut‐brain axis could influence the course of MDD through metabolites
Nazanin Zahra Keshvari +6 more
wiley +1 more source
Alpha-1-antitrypsin deficiency
, 2021 The subject of this review is alpha-1-antitrypsin deficiency (A1AD), which is a rare hereditary disease with great impact in adults, especially smokers, quality of life and longevity. Early diagnosis is crucial for treatment outcome.
Jensen, Jens-Ulrik +5 more
core +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.Messenger RNA therapeutics are rapidly expanding beyond infectious diseases into oncology, autoimmune disorders, protein replacement therapy, cardiovascular and neurological diseases, and regenerative medicine. Advances in RNA engineering and targeted delivery are driving the development of safe, programmable, and precision therapeutics for diverse ...
Gedion Mengistu Dejen
wiley +1 more source
Alpha-1 antitrypsin phenotypes and alcoholic pancreatitis
, 1991 Altered frequencies of alpha-1 antitrypsin phenotypes have been reported in patients with chronic pancreatitis, suggesting a possible genetic basis for individual susceptibility to this disease.
Pirola, R. C. +5 more
core +1 more source
Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.This study evaluated 11 extracellular vesicle (EV) isolation methods which generate plasma‐derived EV‐containing preparations with varying degrees of contaminants. No single approach optimized purity and proteome coverage. In this paper we use proteomics to present an Evidence‐Based Framework to select plasma EV isolation methods based on downstream ...
Scheila Julia Werle +5 more
wiley +1 more source
Alpha-1-antitrypsin replacement therapy: current status
, 2006 PURPOSE OF REVIEW: Alpha-1-antitrypsin deficiency is a relatively common genetic disease that predisposes to the development of early-onset emphysema and, in some instances, liver disease.
Hatem Abusriwil +3 more
core +1 more source
Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.Wetzel et al. outline how individual omics methods contribute to the diagnosis of patients with rare, and particularly mitochondrial diseases, with a focus on how spatial proteomics is joining this multi‐omics stack. ABSTRACT Proteomics by mass spectrometry has rapidly matured from a niche method into a standard tool.
Simon Wetzel +2 more
wiley +1 more source