Results 121 to 130 of about 480,558 (290)

Alpha 1 Antitrypsin Deficiency Pathophysiology, Symptoms, Diagnosis, Treatment

Quality in Sport
Introduction: This review paper aims to emphasize how Alpha-1-antitrypsin deficiency is how can lead to serious disease states, indicating the pathophysiology, symptoms, diagnostic possibilities, therapeutic methods and proving that early diagnostics for
Kamil Kościelecki, Agnieszka Kalisz, Aleksandra Okońska, Julia Kozakiewicz, Iwona Skorulska, Patrycja Długozima, Aleksandra Głowacka, Weronika Barbara Grywińska, Paulina Grzeszczuk, Klaudia Mączewska   +9 more
doaj   +1 more source

Alpha 1-antitrypsin retention in an ectopic liver

Diagnostic Pathology, 2011
Ectopic livers are infrequently reported in the literature. The reported size for ectopic livers range from a few millimeters up to several centimeters.
Cathomas Gieri, Dettmer Matthias, Willi Niels   +2 more
doaj   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, EarlyView.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma

Tumor Biology, 2017
Cholangiocarcinoma is a primary malignant tumor of the bile duct epithelium. Cholangiocarcinoma is usually detected at an advanced stage when successful treatment is no longer possible.
Marut Laohaviroj, Jeremy Potriquet, Xinying Jia, Sutas Suttiprapa, Yaovalux Chamgramol, Chawalit Pairojkul, Paiboon Sithithaworn, Jason Mulvenna, Banchob Sripa   +8 more
doaj   +1 more source

Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan [PDF]

, 2000
Objective: To determine serum level of the protease inhibitor, to identify phenotypes and determine their frequencies. Study Design: A prospective study. Setting: PMRC Research Centre, JPMC and the Aga Khan University Hospital Karachi.
Shahid, Anjum, Siddiqui, Anwar Ali, Waqar, Mohammad, Zuberi, Sarwar i J   +3 more
core  

Measurement of the Proteinase Inhibitors of the Bovine Pancreas by Radioimmunoassay [PDF]

, 1976
Bovine pancreas contains two polypeptide trypsin inhibitors that are not homologous and differ in their inhibitory activity towards chymotrypsin, kallikrein, elastase, and other serine proteinases. The Kunitz inhibitor and the Kazal inhibitor are present
Fink, Edwin, Greene, Lewis J., Peeters, H.   +2 more
core   +1 more source

Portuguese consensus document for the management of alpha-1-antitrypsin deficiency.

Pulmonology, 2018
Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several
A. P. Lopes, M. Mineiro, F. Costa, J. Gomes, C. Santos, C. Antunes, D. Maia, R. Melo, M. Canotilho, E. Magalhães, I. Vicente, Cristina Valente, B. Gonçalves, B. Conde, C. Guimarães, C. Sousa, J. Amado, M. Brandão, M. Sucena, M. Oliveira, Susana Seixas, Susana Seixas, V. Teixeira, L. Telo   +23 more
semanticscholar   +1 more source

The Alpha‐1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD

Alimentary Pharmacology &Therapeutics, EarlyView.
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Tina Jasmin Haunold, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Nina Dominik, Michael Schwarz, Georg Kramer, Christian Sebesta, Paul Thöne, Matthias Pinter, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer   +18 more
wiley   +1 more source

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. [PDF]

, 2000
BACKGROUND: Ischemia followed by reperfusion (I/R) causes apoptosis, inflammation, and tissue damage leading to organ malfunction. Ischemic preconditioning can protect against such injury.
BUURMAN, WA, DAEMEN, M, Denecker, Geertrui, HEEMSKERK, VH, VAN 'T VEER, C, Vandenabeele, Peter, WOLFS, TGAM   +6 more
core   +3 more sources

Alpha-1 Antitrypsin Therapy for Autoimmune Disorders.

Chronic obstructive pulmonary diseases, 2018
Autoimmune diseases are conditions caused by an over reactive immune system that attacks self-tissues and organs. Although the pathogenesis of autoimmune disease is complex and multi-factorial, inflammation is commonly involved.
Sihong Song
semanticscholar   +1 more source