Results 131 to 140 of about 49,741 (289)

Tumor Endothelial Cells Induce M2 Macrophage Polarization via IL‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma

Cancer Science, EarlyView.
Tumor endothelial cells (TECs) promote the polarization of macrophages to M2 subtype by secreting IL‐4. Downregulation of IL‐4 in TECs suppressed M2 polarization and tumor progression. A high abundance of both TECs and M2 macrophages in HCC specimens is associated with poor prognosis.
Daijiro Matoba, Takehiro Noda, Shogo Kobayashi, Yoshihiro Sakano, Kenichi Matsumoto, Chihiro Yamanaka, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Hidenori Takahashi, Tadafumi Asaoka, Junzo Shimizu, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi   +17 more
wiley   +1 more source

FAM20C Modulates Neuronal Differentiation in Hypoxic–Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A‐Dependent H3K9me3 Regulation

Cell Proliferation, EarlyView.
FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng, Mei Wang, Gen Li, Si‐jia Chu, Di Wu, Xiao‐han Hu, Li‐xiao Xu, Mei Li, Xing Feng   +8 more
wiley   +1 more source

A review of multidisciplinary care in metabolic dysfunction‐associated steatohepatitis and cardiometabolic disease, with a focus on Canada

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Cardiometabolic disease (CMD) is associated with an increased risk of metabolic dysfunction‐associated steatohepatitis (MASH). Most patients develop MASH in association with type 2 diabetes and obesity. Optimal disease management requires effective multidisciplinary collaboration between primary care physicians and specialists from different ...
James Kim, Paolo Raggi, Anne‐Marie Carreau, Sean Wharton, Alice Y. Y. Cheng, Mark G. Swain   +5 more
wiley   +1 more source

Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad

European Journal of Clinical Investigation, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano, Enes Erul, Roberto Nilo, Davide Nilo, Vincenzo Russo, Luca Rinaldi, Carlo Acierno, Erman Akkus, Katerina Koudelkova, Federica Cerini, Alessandro Rizzo, Ferdinando Carlo Sasso, Leonilde Bonfrate, Antonio Giordano, Hatime Arzu Yaşar, Caterina Conte   +15 more
wiley   +1 more source

ASSOCIATION OF SERUM ALPHA FETOPROTEIN (AFP) LEVELS WITH SIZE OF HEPATOCELLULAR CARSINOMA

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the association between high levels of serum Alpha Fetoprotein (AFP) and tumor size in hepatocellular carcinoma (HCC). Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Gastroenterology and
Khawar Sahbbir, Asim Shehzad, Mehdi Nqvi, Muhammad Sohail Khalid, Nadeem Zia, Ehtesham Haider, Asif Farooq   +6 more
doaj  

Biamnial alpha fetoprotein concentration in twins, one with multiple malformations. [PDF]

, 1984
J. Huber, P Wagenbichler, F. Bartsch
openalex   +1 more source

Mitochondrial Oxidative Stress in Circulating Leukocytes as a Prognostic Marker in Hepatocellular Carcinoma

Hepatology Research, EarlyView.
ABSTRACT Background and Aims The relationship between oxidative stress (OS) and hepatocellular carcinoma (HCC) is well known, influencing both, hepatocarcinogenesis and subsequent tumor progression. Less understood is its potential role in antitumor defense mechanisms.
Víctor Merino, Carlos Abril, Gloria Segarra, Maria Pilar Ballester, Joan Tosca, Pilar Aguilar, Pascual Medina, Paloma Lluch   +7 more
wiley   +1 more source

Αlpha-fetoprotein Producing Gastric Cancer with Yolk Sac Component: Two Rare Case Reports

Middle East Journal of Cancer, 2016
Alpha-fetoprotein producing gastric cancer accounts for less than 10% of the gastric adenocarcinomas. Different histologic subtypes may exist, the least common of which is yolk sac morphology.
Bita Geramizadeh, Mohammad Hossein Anbardar, Mohadesseh Mashayekhi   +2 more
doaj  

A primary lung carcinoma producing alpha-fetoprotein, carcinoembryonic antigen, and human chorionic gonadotropin. Immunohistochemical and biochemical studies [PDF]

, 1987
Tomohiro Yoshimoto, Kazuya Higashino, Toshikazu Hada, Shinsuke Tamura, Kenji Nakanishi, Masao Mitsunobu, Kunio Uematsu, Takamasa Matsuoka, Kazuhisa Taketa   +8 more
openalex   +1 more source

Impact of Surgical Resection on Hepatocellular Carcinoma Following Systemic Drug Therapy: A Multicenter Retrospective Observational Study

Hepatology Research, EarlyView.
ABSTRACT Aim This study is aimed to evaluate the safety and outcomes of surgical resection in patients with hepatocellular carcinoma (HCC) treated with systemic therapy, address the therapeutic benefit, and identify candidates for surgery after systemic treatment.
Takamichi Ishii, Junichi Shindoh, Ikuo Nakamura, Seiko Hirono, Masaki Wakasugi, Akihiko Ichida, Takashi Hamada, Hajime Matsushima, Takahiro Nishio, Yukio Tokumitsu, Hidenori Takahashi, Yuji Morine, Shinichiro Yamada, Akiyoshi Nakakura, Susumu Eguchi, Kiyoshi Hasegawa, Etsuro Hatano   +16 more
wiley   +1 more source