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Hereditary persistence of alpha‐fetoprotein
Pediatric Blood & Cancer, 2009AbstractHereditary persistence of alpha‐fetoprotein (HPAFP) is a rare benign autosomal dominant disorder. Here we report a 7‐year‐old healthy female who was found to have elevated alpha‐fetoprotein (AFP) of 55–88 ng/ml over a 2‐year period. Subsequently, AFP was also determined to be elevated in another 4 out of 8 family members in three generations ...
Sarah W. Alexander, Xiaxin Li
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Enzymoimmunoassay of human alpha-fetoprotein
Journal of Immunological Methods, 1975A non-competitive method for the determination of human alpha-fetoprotein (AFP) in serum, using a pure specific antibody linked to glucose oxidase is described. When applied to human AFP, this method gives reproducible results in the range 0.7 to 15 ng/ml, in a relatively short time (6 hr).
R. Masseyeff +2 more
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Alpha-fetoprotein quantitation by radioelectrocomplexing
Journal of Immunological Methods, 1974Abstract A recently described technique which uses electrical current to bring together immune reagents as well as to separate immune complexes from antigen or antibody excess has been used to measure alpha-fetoprotein (AFP) levels in different preparations.
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Biochimie, 1978
Bovine AFP was purified by ion exchange chromatograph on C.M. cellulose and DEAE Sephadex A-50, gel filtration and immunosorbent technique. AFP was homogeneous when studied by gel electrophoresis under non denaturing and denaturing conditions, by ultracentrifugation and by immunological methods.
Serge Aliau, Jacques Marti, Jean Moretti
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Bovine AFP was purified by ion exchange chromatograph on C.M. cellulose and DEAE Sephadex A-50, gel filtration and immunosorbent technique. AFP was homogeneous when studied by gel electrophoresis under non denaturing and denaturing conditions, by ultracentrifugation and by immunological methods.
Serge Aliau, Jacques Marti, Jean Moretti
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Structure and Function of Alpha-Fetoprotein
Annual Review of Medicine, 1977AFP is one of several oncofetal proteins synthesized in large amounts by the fetus. Although synthesis drops markedly shortly after birth, small amounts of AFP continue to be produced in the adult. The function of AFP is unknown, but recent studies suggest the possibility that it may have immunoregulatory properties and/or may influence cell ...
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Alpha-Fetoprotein in the 1990s
1992Alpha-fetoprotein (AFP) is a well-established marker of hepatocellular carcinoma, yolk sac tumor, and other AFP-producing tumors mostly of gastrointestinal origin. The high sensitivity as well as the high specificity of AFP among other cancer markers was established by Abelev et al.
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Fractionation of mouse alpha-fetoprotein
Experientia, 19794 distinct alpha-fetoprotein (AFP) containing fractions were obtained upon ion-exchange chromatography of late-gestational fetal mouse extracts. Despite this chromatographic heterogeneity, the individual AFP isolates were antigenically indistinguishable.
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Alpha-Fetoprotein (AFP) biosensors
Clinica Chimica ActaAlpha-fetoprotein (AFP) is a glycoprotein mainly produced during fetal development, and elevated levels in adults are frequently associated with liver diseases, especially hepatocellular carcinoma (HCC), as well as certain germ cell tumors. Measuring AFP in biological samples is crucial for early diagnosis, monitoring disease progression, and ...
Nava Moghadasian, Niaki +4 more
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Journal of Pediatric Hematology/Oncology
Hepatoblastoma is the most common liver malignancy in children. Treatment typically involves surgery and cisplatin-based chemotherapy. After therapy completion, children undergo repetitive surveillance imaging to screen for relapse, which occurs in <12% of cases.
Monica, Davini +2 more
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Hepatoblastoma is the most common liver malignancy in children. Treatment typically involves surgery and cisplatin-based chemotherapy. After therapy completion, children undergo repetitive surveillance imaging to screen for relapse, which occurs in <12% of cases.
Monica, Davini +2 more
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Alpha-fetoprotein and antenatal screening
Clinica Chimica Acta, 1980R.G. Davidson, W.H.C. Walker
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