Results 111 to 120 of about 10,488 (304)

Glycan composition of serum alpha-fetoprotein in patients with hepatocellular carcinoma and non-seminomatous germ cell tumour [PDF]

Although estimation of serum alpha-fetoprotein (AFP) is widely used in the diagnosis of hepatocellular carcinoma (HCC) and non-seminomatous germ cell tumours (NSGCT), the clinical usefulness of this test is limited by a low specificity.
AP Elhammer, ASF Lok, CJP Smith, CR Nichols, E Alpert, E Tarelli, F Nomura, H Yoshima, JC Bigge, JC Sheu, JE Hansen, JE Hansen, K Okuda, K Shimizu, K Taketa, K Yamashita, K Yamashita, LJ Burditt, MC Kew, MQ Du, N Javadpour, P Ferranti, PH Kay, PH Lange, PJ Johnson, PJ Johnson, PJ Johnson, PJ Johnson, PK Buamah, S Ho, TP Patel, Y Aoyagi   +31 more
core   +2 more sources

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, EarlyView.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Endocrine and bone health in pediatric brain tumour survivors [PDF]

, 2017
In der vorliegenden Arbeit wurde im Rahmen der Querschnittsstudie „Untersuchungen zur Knochengesundheit bei Kindern und Jugendlichen nach onkologischer Erkrankung und Therapie“ die Kohorte der an einem Tumor des zentralen Nervensystems erkrankten Kinder ...
Fritzemeier, Sebastian
core  

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, EarlyView.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

Evaluation of Alpha-fetoprotein and Prothrombin Induced by Vitamin K Absence for Hepatocellular Carcinoma Diagnosis in Patients Admitted to a Large Transplant Center [PDF]

, 2018
Răzvan Cerban, Carmen Ester, Speranța Iacob, Mihaela Ghioca, Liliana Pâslaru, Dumitru Radu, Mugur Grasu, Georgiana Bianca Constantin, Irinel Popescu, Liliana Gheorghe   +9 more
openalex   +1 more source

Pre‐Treatment Liver Stiffness Is a Stronger Predictor of Hepatocellular Carcinoma Development Than Post‐Treatment Liver Stiffness After Hepatitis C Virus Eradication

Hepatology Research, EarlyView.
Higher pre‐treatment liver stiffness measurement (LSM) values, rather than post‐treatment values, independently predicts hepatocellular carcinoma after hepatitis C virus eradication, underscoring the need for continued surveillance in patients with elevated baseline LSM.
Takuma Nakatsuka, Ryo Nakagomi, Keisuke Mabuchi, Yuki Matsushita, Tomoharu Yamada, Kazuya Okushin, Tatsuya Minami, Masaya Sato, Koji Uchino, Yotaro Kudo, Mitsuhiro Fujishiro, Kazuhiko Koike, Ryosuke Tateishi   +12 more
wiley   +1 more source

Porous polyethylene in reconstructive head and neck surgery [PDF]

, 1985
Berghaus, Alexander
core   +1 more source

ヒト肝細胞癌の発癌機序:病理組織像と細胞動態細胞形質像.遺伝子学的性常との対比 [PDF]

, 1996
金沢大学医学部癌遺伝子、癌抑制遺伝子の解析:ras癌遺伝子産物とp53癌抑制遺伝子産物を免疫組織化学的に検討した。p53はAHでは全く発現がなく、肝細胞癌の2%位に発現がみられた。従って、肝発癌ではp53の関与は、発癌後期に関与すると考えられた。ras遺伝子産物は、異型型AHと癌内包型AHの一部の症例で弱く発現されており、肝細胞癌で中等度に発現されていた。以上、rasの発現は、肝発癌の初期におこると思われた。AHのヌードマウスへの移植:最近外科切除AHがなく、実験できなかった。臨床追跡調査 ...
Terada Tadashi, 寺田 忠史
core   +1 more source

Efficacy and Safety of Hypofractionated Radiation Therapy Combined With Immunotherapy for Hepatocellular Carcinoma With Vp4 Portal Vein Tumor Thrombosis

Hepatology Research, EarlyView.
ABSTRACT Background Hepatocellular carcinoma (HCC) with Vp4 portal vein tumor thrombosis (PVTT) has an extremely poor prognosis, and evidence for effective systemic therapy is limited. Preclinical studies suggest that hypofractionated radiation therapy (HFRT) may enhance immune checkpoint inhibitor (ICI) efficacy through immunogenic cell death and ...
Masahiko Tameda, Hideaki Tanaka, Yutaka Toyomasu, Mizuki Kawachi, Hirono Owa, Mone Tsukimoto, Yasuyuki Tamai, Naoto Fujiwara, Ryuta Shigefuku, Suguru Ogura, Yoshihito Nomoto, Hayato Nakagawa   +11 more
wiley   +1 more source

Alpha-Fetoprotein-Producing Rectal Carcinoma. A Case Report.

, 1997
Jun Taguchi, Hirohisa Yano, J. Sueda, Rin Yamaguchi, Masamichi Kojiro, Genzan Shirouzu, Ken Hashimoto   +6 more
openalex   +2 more sources