Results 51 to 60 of about 10,418 (286)

Cancer: The Great Challenge for Immunology [PDF]

, 1977
The existence of immunity to cancer was postulated by the eminent scientists who helped to establish the discipline of immunology. In 1907 Clowes suggested that human resistance to cancer resulted from what we today call “immune surveillance.” During the
Goldstein, Gerald
core   +1 more source

Male-like sexual behavior of female mouse lacking fucose mutarotase [PDF]

, 2010
Background Mutarotases are recently characterized family of enzymes that are involved in the anomeric conversions of monosaccharides. The mammalian fucose mutarotase (FucM) was reported in cultured cells to facilitate fucose utilization and incorporation
B Attardi, C Bodo, C De Mees, CD Toran-Allerand, CH Hubscher, Chankyu Park, D Park, D Pfaff, D Restrepo, Dae-sik Lim, DJ Becker, Dongkyu Park, Dongwook Choi, E Ruoslahti, F Herve, FS vom Saal, G Ashwell, GJ Mizejewski, GJ Mizejewski, H Buteau-Lozano, HE Murrey, I Rodriguez, J Bakker, J Bakker, J Uriel, J Weisz, JB Becker, JP Raynaud, JR Wilson, Junghoon Lee, L Savu, M Olsson, M Yanase, ME Baker, MJ Baum, MM McCarthy, N Bayati, P Gabant, PJ Johnson, PL Smith, R Rampal, RB Simerly, RB Simerly, RB Simerly, RB Simerly, RB Simerly, RG Janzen, S Ogawa, S Ogawa, SJ Wiegand, SK Amateau, SK Swartz, SS Leong, T de Vries, T Nakagawa, T Okajima, WT Swaney, Y Luo, Z Wang   +58 more
core   +3 more sources

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Fifty years of discovery of alpha-fetoprotein as the first tumor marker [PDF]

, 2015
Alpha-fetoprotein represents the most prominent oncobiomarker, widely used in the diagnosis of hepatocellular carcinoma for monitoring of tumor progression, presence of metastasis, assessment of cancer prognosis and successful antitumor therapeutic ...
Galimzyanov, Khalil, Jurisic, Vladimir, Nikulina, Dina, Terentiev, Alexander   +3 more
core   +1 more source

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

Advanced Materials, EarlyView.
A schematic illustration of how noble metals can be used to create nanoparticles (NPs) or nanoclusters (NCs). Noble metal NPs, due to their plasmonic properties, enable photothermal therapy and surface‐enhanced Raman scattering (SERS). In contrast, NCs, which lack a plasmonic resonance band, exhibit fluorescence, making them ideal for bioimaging ...
David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez   +3 more
wiley   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

The Ewha Medical Journal
We report a rare case of gastric adenocarcinoma with enteroblastic differentiation (GAED) that was treated with endoscopic submucosal dissection followed by additional distal gastrectomy with lymph node dissection.
Hae Rin Lee, Gwang Ha Kim, Dong Chan Joo, Moon Won Lee, Bong Eun Lee, Kyung Bin Kim   +5 more
doaj   +1 more source

Maternal serum alpha-fetoprotein levels in fetal hydrocephalus: a retrospective population based study [PDF]

, 2006
BACKGROUND: Although maternal serum alpha-fetoprotein (MSAFP) is a highly sensitive marker for certain congenital malformations such as open neural tube and ventral wall defects, its usefulness as a screening test for fetal hydrocephalus is uncertain. We
Chodirker, Bernard N, Evans, Jane A, MacDonald, Karen M, Szajkowski, Terrence P   +3 more
core   +3 more sources

Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response

Advanced Science, EarlyView.
This study introduces a dendrimer‐peptide conjugate platform (G7‐pPDL1) for avidity‐based capture of PD‐L1‐expressing exosomes. The system exhibits enhanced binding kinetics and exosome capture efficiency, enabling accurate prediction of immunotherapy outcomes.
Jiah Lee, Dongjun Shin, Chae Yeon Son, Hanbit Kang, Jung Hyun Choi, Hyun Sung Park, Seha Bang, Lucia Kim, Tae Hee Lee, Hyuk Soo Eun, Michael J Poellmann, Woo‐jin Jeong, Dong Hyung Kim, Jun Hyeok Lim, Seungpyo Hong, Jiyoon Bu   +15 more
wiley   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source