Results 201 to 210 of about 45,966 (272)
Case report of a 45-year old female Fabry disease patient carrying two alpha-galactosidase A gene mutation alleles. [PDF]
BMC Med Genet, 2016 Oder D +4 more
europepmc +1 more source
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
Thermomyces lanuginosus CBS 395.62/b strain as rich source of alpha-galactosidase enzyme [PDF]
, 2003 Bujna, Erika +5 more
core
The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits
Aging Cell, Volume 25, Issue 2, February 2026.Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen +18 more
wiley +1 more source
Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice
Aging Cell, Volume 25, Issue 2, February 2026.Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang +4 more
wiley +1 more source
Hypertension in adult Fabry’s disease: is cardiotrophin-1 a diagnostic biomarker? [PDF]
, 2014 core +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.Unrestrained Cdc42 activity causes failure of cytotoxic function of old NK cells. This is associated with disruption of microtubular network and impaired mitochondrial ATP resulting in reduced conjugation and impaired degranulation of lytic vesicles.
Albert Kallon Koroma +15 more
wiley +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.In D‐galactose‐induced aging model, periodic therapeutic phlebotomy exerts significant and comprehensive anti‐aging effects by inducing bone marrow microenvironment restoration, which rebalances hematopoiesis to restore peripheral blood function and ameliorate systemic aging phenotypes.
Ji‐Ru Cai +7 more
wiley +1 more source
Mechanism of action of alpha-galactosidase.
Indian journal of biochemistry & biophysics, 1988 C D, Mathew, K, Balasubramaniam
openaire +1 more source