Results 211 to 220 of about 900,860 (290)

A Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders. [PDF]

J Inherit Metab Dis
McCarron EP, Blau N, Eden ER, Platt FM, Aerts JM, Jones SA, Ferreira CR, Stepien KM.   +7 more
europepmc   +1 more source

Effects of a Dietary Supplement on Systemic Aging Related Biomarkers and Skin Aging Outcomes in Middle‐Aged Women: In Vitro and Clinical Studies

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Interest in dietary supplements targeting both skin and biological aging biomarkers is rapidly growing, yet existing studies lack rigorous clinical validation of combined oral–topical regimens and concurrent assessment of skin and systemic biomarkers.
Jie‐Hua Chen, Liugang Ding, Pingping Lv, Wenzhi Li, Meiling Tai, Ran Yin, Yi Yu, Yunru Huang, Jinluan Zheng, Erman Wang, Huan Liu, Jiaojiao Fu, Hongjue Wang, Ruopan Huang, Jun Ma   +14 more
wiley   +1 more source

α-Mangostin attenuates <i>Pseudomonas aeruginosa</i> virulence by targeting PqsR and inhibiting PQS-mediated quorum sensing. [PDF]

Virulence
Liu D, Li Z, Cheng J, Xiao W, Zheng Y, Liu G, Zeng J, Li S, Wang Z, Wang Y, Mao R, Cao D, Lin J.   +12 more
europepmc   +1 more source

GmERF109 Positively Enhances Soybean Resistance to Phytophthora sojae by Transcriptionally Activating GmG4DT‐Like to Promote Glyceollin I Accumulation

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
GmERF109 is strongly induced in P. sojae‐resistant but not susceptible soybeans. GmERF109 functions as a nuclear AP2/ERF transcription factor, P. sojae directly binding the GCC‐box to activate GmG4DT‐like expression. The GmERF109–GmG4DT‐like module enhances glyceollin I accumulation for soybean resistance to P. sojae.
Xin Fang, Rui Liang, Yiling Cheng, Hong Gao, Chuanzhong Zhang, Jingcan Sun, Junjun Song, Gengpu Zhang, Meng Liu, Yuxin Zhao, Yan Sun, Xiran Wang, Xiaoyu Chen, Kexin Ma, Shuo Wang, Kexin Li, Jiapeng Tong, Junjiang Wu, Pengfei Xu, Shuzhen Zhang   +19 more
wiley   +1 more source

Impact of migalastat therapy on corneal deposits in a female with Fabry disease: A case report. [PDF]

Mol Genet Metab Rep
Vitturi N, Gugelmo G, Zanini F, Carraro G, Lenzini L, Leonardi A.   +5 more
europepmc   +1 more source

Mechanism of action of alpha-galactosidase.

Indian journal of biochemistry & biophysics, 1988
C D, Mathew, K, Balasubramaniam
openaire   +1 more source

Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16INK4a Promoter

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Magnesium (Mg2+) attenuates renal injury in ischemia–reperfusion and radiation‐induced kidney injury models in association with reduced DNA damage response markers, cellular senescence, inflammation, and fibrosis. Mg2+ treatment is associated with reduced H3K4me3 enrichment at the p16INK4a promoter, attenuation of senescence‐associated pathways, and ...
Makoto Matsubara, Kensuke Sasaki, Shigehiro Doi, Takeshi Ike, Maria Yoshida, Akira Takahashi, Yosuke Osaki, Naoki Ishiuchi, Aiko Okubo, Yujiro Maeoka, Takuto Chiba, Ayumu Nakashima, Takao Masaki   +12 more
wiley   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Modeling Fabry nephropathy: insights from experimental systems towards precision nephrology. [PDF]

Dis Model Mech
Elsaid H, Furriol J, Eikrem Ø, Tøndel C, Svarstad E.   +4 more
europepmc   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source