Results 211 to 220 of about 954,264 (289)

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source

FGF13 Alleviates the Aging Process in Mice by Regulating Astrocyte Function in the Medial Prefrontal Cortex via Phafin2 Signaling Pathway

Aging Cell, Volume 25, Issue 11, November 2026.
FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng, Zheng Tu, Yang Fang, Caixiang Zhuang, Yuchao Zhang, Yibo Ying, Zhiyi Feng, Ziyang Jin, Yanyan Zheng, Zhouguang Wang   +9 more
wiley   +1 more source

Molecular and Structural Characterization of Five Novel <i>GLA</i> Gene Variants in Fabry Disease. [PDF]

Int J Mol Sci
Anania M, Pagliardini V, Spada M, Econimo L, Giacalone I, Vinci M, Colomba P, Cappelletti F, Tonelli C, Mancuso M, Duro G, Marsana EM, Moschetti M, Duro G.   +13 more
europepmc   +1 more source

Endothelial Matrin‐3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Endothelial Matrin‐3 suppresses cellular senescence and protects against atherosclerosis. Matrin‐3 deficiency induces endothelial senescence, mitochondrial dysfunction, and activation of p53‐, cell cycle‐, and senescence‐related pathways. In atherosclerosis‐prone mice, endothelial Matrin‐3 deletion promotes atherosclerotic lesion formation and disrupts
Xiao Cheng, Fatema Yeasmin Tanni, Rachelle Nelson Zoni, Elham Abdollahi, Eli Childs, Xinghui Sun   +5 more
wiley   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Case report of a 45-year old female Fabry disease patient carrying two alpha-galactosidase A gene mutation alleles. [PDF]

BMC Med Genet, 2016
Oder D, Vergho D, Ertl G, Wanner C, Nordbeck P.   +4 more
europepmc   +1 more source

High Resolution Ion Mobility Enables the Separation of α-Galactose Containing Glycans from Their Non-α-Galactose Isomers. [PDF]

J Biomol Tech
Park K, Orlando R.
europepmc   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources