Results 201 to 210 of about 900,860 (290)

High Resolution Ion Mobility Enables the Separation of α-Galactose Containing Glycans from Their Non-α-Galactose Isomers. [PDF]

J Biomol Tech
Park K, Orlando R.
europepmc   +1 more source

Secreted Frizzled‐Related Protein 2 (SFRP2) Induces Follistatin‐Like 1 (FSTL1) to Regulate Dihydrotestosterone (DHT)‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Secreted frizzled‐related protein 2 (SFRP2) emerges as a critical regulator in androgenetic alopecia (AGA) by promoting stability and activity of the follistatin‐like protein FSTL1, establishing a novel SFRP2–FSTL1 axis that exacerbates dihydrotestosterone (DHT)‐driven pathogenic changes in dermal papilla cells (DPCs).
Youming Huang, Qiong Bian, Yeyu Shen, Xiaoxia Ding, Yan Teng, Danfeng Xu, Xianhong Yang, Yibin Fan   +7 more
wiley   +1 more source

Fabry Disease Diagnosed With Lung Nodule: A Unique Presentation in a Young Female Patient. [PDF]

Cureus
Joppich J, Mehta S, Mandavilli N, Rojas Alvarez F, Mehta V.   +4 more
europepmc   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes

Aging Cell, Volume 25, Issue 9, September 2026.
SIRT1 binds the LINE‐1 5′‐UTR and recruits the heterochromatin modifiers Lamin B1 and KAP1 to maintain H3K9me3 levels, thereby suppressing LINE‐1 retrotransposition. SIRT1 deficiency enhances LINE‐1 transcription, leading to upregulation of senescence‐associated secretory phenotype factors, activation of the cGAS‐STING pathway, and consequent cellular ...
Xiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng   +8 more
wiley   +1 more source

Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age‐Related Pathologies

Aging Cell, Volume 25, Issue 9, September 2026.
PTCHD4 is induced by aging‐ and injury‐associated stresses and acts as a senescence‐associated transmembrane regulator. Through AKT activation, PTCHD4 promotes cellular senescence, SASP, functional decline, and pulmonary fibrosis, whereas PTCHD4 deficiency dampens AKT signaling and alleviates senescence‐associated pathological phenotypes.
Mingyue Wang, Zhaoyun Yang, Qikai Wang, Zeping Li, Zhihua Huang, Le Wang, Xiaoning Sun, Donglin Yu, Wenhua Yu, Xiaoxia Bao, Zebin Mao, Yang Li   +11 more
wiley   +1 more source

Long-Term Cardiac Remodeling During Migalastat Therapy in a Heterozygote Woman With Fabry Disease (N224S): A 9 Year Case Report. [PDF]

Am J Case Rep
Tan C, Thanabalasingam V, Sella Kapu C, Hiskens M, Zhang Z.   +4 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Renal involvement in Fabry disease from Tunisian families: Six case reports. [PDF]

World J Nephrol
Tlili S, Ghabi H, Mami I, Ben Hmida F, Rais L, Zouaghi MK.   +5 more
europepmc   +1 more source

ADSC‐Derived CCL8 Regulates HIF‐1α Signaling and Promotes Colorectal Cancer Progression in a 3D Coculture Platform

Cancer Science, Volume 117, Issue 9, Page 2480-2495, September 2026.
Schematic illustration showing how CRC‐associated ADSC‐derived CCL8 promotes colorectal cancer cell migration through ERK/HIF‐1α signaling in a 3D coculture platform. ABSTRACT This study aimed to recapitulate adipose‐tumor interactions within the colorectal cancer (CRC) tumor microenvironment (TME) and to elucidate the role of adipose‐derived stem ...
Jeong‐Eun Yun, Yeseon Son, Jieun Seo, Ki Yong Hong, Junji Fukuda, Do‐Won Jeong, Jong‐Wan Park, Yang‐Sook Chun   +7 more
wiley   +1 more source