Results 51 to 60 of about 28,650 (180)

In vitro digestibility of Urochloa decumbens inoculated with fungi isolated from the gastrointestinal tract of sheep

Annals of Applied Biology, EarlyView.
The forage digestibility decreases in the dry season. Fungus isolates from the gastrointestinal tract of healthy sheep were evaluated. Aspergillus terreus isolate was identified by analysis of rDNA and encoding β‐tubulin gene and Trichoderma longibrachiatum was identified by analysis of rDNA and elongation factor 1‐α gene. The T.
Claudio Eduardo Silva Freitas, Mara Lúcia Albuquerque Pereira, Higor Alexandre Rodrigues Maia, Angélica Alves De Moura Freitas, Herymá Giovane De Oliveira Silva, Fernando Santos Magaço, Vera Lúcia Dos Santos, Aline Daniela Lopes Júlio, Felipe Gomes Da Silva, Luciana Castro Geraseev, Eduardo Robson Duarte   +10 more
wiley   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound

Aging Cell, EarlyView.
Optimized low‐frequency ultrasound rejuvenates induced senescent cells and aged mice. Our results show that LFU reverses 15 aspects of senescent cells including growth and revitalizes aged mice. ABSTRACT The presence of senescent cells causes age‐related pathologies since their removal by genetic or pharmacological means, as well as possibly by ...
Sanjay K. Kureel, Rosario Maroto, Maisha Aniqua, Simon Powell, Ekta Singh, Felix Margadant, Brandon Blair, Blake B. Rasmussen, Michael P. Sheetz   +8 more
wiley   +1 more source

Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function

Aging Cell, EarlyView.
Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu, Xinglin Zhu, Shanshan Pan, Yan Chen, Cai Luo, Yangyang Zhao, Jingci Xing, Kaijia Shi, Shuya Zhang, Jiaqi Li, Jinxuan Chai, Xuebin Ling, Jianmin Qiu, Yan Wang, Zhihua Shen, Wei Jie, Junli Guo   +16 more
wiley   +1 more source

Alpha-galactosidase A deficiency (Fabry's disease) in a black Zimbabwean.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1993
We describe a patient with Fabry's disease with renal and myocardial involvement. He has been followed up for 10 years. This metabolic defect has not been noted before in southern Africa; the clinical course is similar to that of western European and American cases.
Borok, MZ, Gabriel, R
openaire   +2 more sources

BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration

Aging Cell, EarlyView.
This study identifies BRD4 as a key regulator in intervertebral disk degeneration (IDD), linking its upregulation to NP cell senescence and disrupted ECM metabolism through the BRD4/MAP2K7/PGF signaling cascade, offering a potential therapeutic target for IDD treatment.
Guangzhi Zhang, Lei Li, Zhili Yang, Zhenyu Cao, Xuchang Hu, Yonggang Wang, Xuewen Kang   +6 more
wiley   +1 more source

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, EarlyView.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Studies on human liver alpha-galactosidases. II. Purification and enzymatic properties of alpha-galactosidase B (alpha-N-acetylgalactosaminidase). [PDF]

Journal of Biological Chemistry, 1979
C C Sweeley, K J Dean
openaire   +2 more sources

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

Aging Cell, EarlyView.
The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier, Rojina Ranjit, Daniel B. Owen, Jenna L. Wilson, Megan A. Stiles, Anthony M. Masingale, Zachary Thomas, Anne Bredegaard, David M. Sherry, Sreemathi Logan   +9 more
wiley   +1 more source