Results 121 to 130 of about 114,325,321 (319)

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones. [PDF]

Int J Mol Sci, 2022
Monticelli M, Liguori L, Allocca M, Bosso A, Andreotti G, Lukas J, Monti MC, Morretta E, Cubellis MV, Hay Mele B.   +9 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Creation of a Recombinant Bacteriophage to Express Beta-Galactosidase

, 2014
Human illness caused by the consumption of food contaminated with pathogenic bacteria is a worldwide problem that requires new detection methods to solve.
Heather Talbott (10083040), Catherine Swedberg (10083037)   +1 more
core   +1 more source

Natural antibacterial silk produced by feeding silkworms with human hair derived carbon dots

Responsive Materials, EarlyView.
Blue‐fluorescent and antibacterial carbon dots, prepared from Crinis Carbonisatus (a traditional Chinese medicine made by calcinating human hair), are fed to silkworms to produce multifunctional silk, which retains its inherent mechanical properties, exhibits blue fluorescence, possesses antibacterial activity, and promotes the wound healing of rats as
Zhao‐Fan Wu, Xiao‐Feng Shi, Xiao‐Xiao Luo, Xi‐Rong Zhang, Yuan‐Qing Mao, Huan‐Ming Xiong   +5 more
wiley   +1 more source

Purification and properties of the anionic form of alpha-galactosidase from germinating guar (Cyamopsis tetragonolobus).

, 1990
Three forms of alpha-galactosidase occur in germinating guar representing 100% of the activity present. They are alpha-galactosidase-A (anionic, 28%), alpha-galactosidase-C1 (cationic, 12%) and alpha-galactosidase-C2 (cationic, 60%).
Shivanna, B. D., Ramakrishna, M., Ramadoss, C. S.   +2 more
core   +1 more source

Fabry disease in the haemodialysis population: outcome of a UK screening study (SoFAH)

BMC Nephrology
Background and hypothesis Fabry disease (FD) is an X-linked inherited disorder with an estimated prevalence among the end-stage kidney disease (ESKD) population of 0.3% in men and 0.1% in women [1].
K.P. Ng, M. Sandhu, D. Banerjee, J.O. Burton, L. Crowley, T. Doulton, M.A. Hameed, R. Hamer, M. Menon, J. Nicholas, S.B. Ramakrishna, K. Shivakumar, T. Geberhiwot, I. Dasgupta   +13 more
doaj   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source