Results 141 to 150 of about 114,325,321 (319)

Alpha Kappa Alpha: Sisterhood and Service DVD, 2008

, 2008
This documentary tells of AKA's founding at Howard University and celebrates the sorority's history and commitment to service and accomplishment.Archival master image scanned in reflective mode as 48-bit RGB color TIFF using Epson 11000 XL. Display image
Alpha Kappa Alpha
core   +1 more source

Ritual of Alpha Epsilon Iota

, 1917
Documents of Alpha Epsilon Iota, a women's medical fraternity. This version was adopted at Ann Arbor, June 1917, revised at Chicago, 1927, standardized at Ann Arbor ...
Alpha Epsilon Iota
core  

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Whole Blood alpha-D-Galactosidase A activity for the identification of Fabry patients

, 2010
Rationale: Fabry disease is a rare X-linked lysosomal storage disorder due to deficiency of α-D-galactosidase A (α-Gal A) and the consequent progressive accumulation of globotriaosyl ceramide in plasma and lysosomes of all tissues.
L. Massaccesi, G. Goi, A. P. Burlina, C.J. Baquero, A. Burlina   +4 more
core   +2 more sources

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

SGLT2 Inhibitors and Cardiovascular Outcomes in Patients With Fabry Disease: Observations From a Federated Research Network

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aim Fabry disease (FD) is frequently complicated by renal impairment and cardiovascular events; however, evidence on sodium–glucose cotransporter‐2 inhibitors (SGLT2i) in this population is scarce. Accordingly, we assessed the association between SGLT2i exposure and cardiovascular outcomes in adults with FD. Methods We conducted
Leandra Serio, Michele Rossi, Amir Askarinejad, Enrico Tartaglia, Tommaso Bucci, Enrica Marrone, Dinesh K. Kalra, Claudio Ferri, Gregory Y. H. Lip   +8 more
wiley   +1 more source

alpha-Galactosidase A deficient mice: a model of Fabry disease.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Toshio Ohshima, Gary J. Murray, William D. Swaim, G. Longenecker, J. Quirk, C. Cardarelli, Y. Sugimoto, I. Pastan, M. Gottesman, R. Brady, A. B. Kulkarni   +10 more
semanticscholar   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice.

American Journal of Human Genetics, 2001
Y. Ioannou, K. M. Zeidner, Ronald E. Gordon, R. Desnick   +3 more
semanticscholar   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source