Results 151 to 160 of about 118,748,616 (241)

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

The Effect of pH Changes on the Levels of Alpha-Galactosidase A in a Patient with Fabry's Disease, Post Renal Transplant

, 1989
Fabry's disease (alpha-galactosidase A deficiency) leads to early renal failure. Unfortunately, kidney transplants do not always reliably supply the deficient enzyme. To assess urinary and serum activity of alpha-galactosidase A by the transplant as well
Brown, Lois E.
core  

Serological Assessment of Alpha Galactosidase, N-Glycolylneuraminic Acid, and Histopathological Observations in Xenograft Recipients. [PDF]

Cureus
Ramesh B, Ramanan S, Srimurugan B, Fakoya AO.   +3 more
europepmc   +1 more source

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

Reversing Pathology in an Aggravated Fabry Mouse Model Using Low-Dose Engineered Human Alpha-Galactosidase A AAV Gene Therapy. [PDF]

Biomedicines
Ruangsiriluk W, Deshpande M, Boukharov N, Rajarshi G, Mukherji S, Yuan S, Wiseman J, Chen N, Park E, Cho H, Islam R.   +10 more
europepmc   +1 more source

SGLT2 Inhibitors and Cardiovascular Outcomes in Patients With Fabry Disease: Observations From a Federated Research Network

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aim Fabry disease (FD) is frequently complicated by renal impairment and cardiovascular events; however, evidence on sodium–glucose cotransporter‐2 inhibitors (SGLT2i) in this population is scarce. Accordingly, we assessed the association between SGLT2i exposure and cardiovascular outcomes in adults with FD. Methods We conducted
Leandra Serio, Michele Rossi, Amir Askarinejad, Enrico Tartaglia, Tommaso Bucci, Enrica Marrone, Dinesh K. Kalra, Claudio Ferri, Gregory Y. H. Lip   +8 more
wiley   +1 more source

Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease. [PDF]

Mol Ther Methods Clin Dev
Liefhebber JMP, Brasser G, Spronck EA, Ottenhoff R, Paerels L, Ferraz MJ, Schwarz LK, Efthymiopoulou N, Kuo CL, Montenegro-Miranda PS, Evers MM, Aerts JMFG, Liu YP.   +12 more
europepmc   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Immobilization/stabilization on Eupergit C of the beta-galactosidase from B-circulans and an alpha-galactosidase from Aspergillus oryzae

Two synthetically useful glycosidases, the beta-galactosidase from Bacillus circulans and an alpha-galactosidase from Aspergillus oryzae have been immobilized on Eupergit C.

core  

Flow Cytometry-Based Assay to Detect Alpha Galactosidase Enzymatic Activity at the Cellular Level. [PDF]

Cells
Fekete N, Li LK, Kozma GT, Fekete G, Pállinger É, Kovács ÁF.   +5 more
europepmc   +1 more source