Results 171 to 180 of about 114,325,321 (319)

Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A.

Proceedings of the National Academy of Sciences of the United States of America, 1985
David H. Calhoun, David F. Bishop, H. S. Bernstein, M. Quinn, Petros Hantzopoulos, R. J. Desnick   +5 more
semanticscholar   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Serological Assessment of Alpha Galactosidase, N-Glycolylneuraminic Acid, and Histopathological Observations in Xenograft Recipients. [PDF]

Cureus
Ramesh B, Ramanan S, Srimurugan B, Fakoya AO.   +3 more
europepmc   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Reversing Pathology in an Aggravated Fabry Mouse Model Using Low-Dose Engineered Human Alpha-Galactosidase A AAV Gene Therapy. [PDF]

Biomedicines
Ruangsiriluk W, Deshpande M, Boukharov N, Rajarshi G, Mukherji S, Yuan S, Wiseman J, Chen N, Park E, Cho H, Islam R.   +10 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Flow Cytometry-Based Assay to Detect Alpha Galactosidase Enzymatic Activity at the Cellular Level. [PDF]

Cells
Fekete N, Li LK, Kozma GT, Fekete G, Pállinger É, Kovács ÁF.   +5 more
europepmc   +1 more source

Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia‐inducible factor‐1a (HIF1a) integrates physiological and pathological inputs in skeletal muscle, including exercise, circadian timing, cytotoxins and disease. These inputs alter mitochondrial oxidative function, redox state, reactive oxygen species, and local oxygen availability, leading to intermittent or sustained HIF1a
Nicole Welch, Pugazhendhi Kannan, Seshu Vardhan Pothabathula, Annette Bellar, Abhishek A. Chakraborty, Saurabh Mishra, Srinivasan Dasarathy   +6 more
wiley   +1 more source